Results 71 to 80 of about 2,380,407 (323)

Issues with rounding in the GCC implementation of the ISO 18037:2008 standard fixed-point arithmetic

, 2020
We describe various issues caused by the lack of round-to-nearest mode in the \textit{gcc} compiler implementation of the fixed-point arithmetic data types and operations.
Mikaitis, Mantas
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Data selection strategies for minimizing measurement time in materials characterization

Scientific Reports
Every new material needs to be assessed and qualified for an envisaged application. A steadily increasing number of new alloys, designed to address challenges in terms of reliability and sustainability, poses significant demands on well-known analysis ...
Alexander Liehr, Kristina Dingel, Daniel Kottke, Sebastian Degener, David Meier, Bernhard Sick, Thomas Niendorf   +6 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The extreme vulnerability of interdependent spatially embedded networks

, 2012
Recent studies show that in interdependent networks a very small failure in one network may lead to catastrophic consequences. Above a critical fraction of interdependent nodes, even a single node failure can invoke cascading failures that may abruptly ...
A Bashan, A Bashan, A Bunde, A Vespignani, Amir Bashan, B Nienhuis, CD Brummitt, CM Schneider, CM Schneider, D Li, D Stauffer, I Dobson, J Gao, J Gao, J Hao, M Barthelemy, MPM Den Nijs, R Cohen, R Cohen, R Khanin, R Milo, R Parshani, R Parshani, S Rinaldi, S Son, Sergey V. Buldyrev, Shlomo Havlin, SN Dorogovtsev, SV Buldyrev, SV Buldyrev, U Alon, V Rosato, W Li, X Huang, Y Hu, Yehiel Berezin   +35 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Configurable Multi-Layer Perceptron-Based Soft Sensors on Embedded Field Programmable Gate Arrays: Targeting Diverse Deployment Goals in Fluid Flow Estimation

Sensors
This study presents a comprehensive workflow for developing and deploying Multi-Layer Perceptron (MLP)-based soft sensors on embedded FPGAs, addressing diverse deployment objectives. The proposed workflow extends our prior research by introducing greater
Tianheng Ling, Chao Qian, Theodor Mario Klann, Julian Hoever, Lukas Einhaus, Gregor Schiele   +5 more
doaj   +1 more source

Experience with Abrupt Transition to Remote Teaching of Embedded Systems [PDF]

, 2022
Jan Koniarik, Daniel Dlhopolček, Martin Ukrop   +2 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source