Results 91 to 100 of about 1,295,202 (338)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
An Optimal Skorokhod Embedding for Diffusions
, 2002 Given a Brownian motion $B_t$ and a general target law $\mu$ (not necessarily centered or even integrable) we show how to construct an embedding of $\mu$ in $B$.
Cox, A. M. G., Hobson, D. G.
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VINEA: a policy-based virtual network embedding architecture [PDF]
, 2013 Network virtualization has enabled new business models by allowing infrastructure providers to lease or share their physical network. To concurrently run multiple customized virtual network services, such infrastructure providers need to run a virtual ...
Esposito, Flavio +2 more
core +1 more source
Semantics and Pragmatics, 2009 Over the last decade, various proposals have been made for supplanting the classical Gricean theory of scalar implicature with conventionalist (i.e. lexicalist or syntax-based) treatments. In contradistinction to the classical view, conventionalist theories predict that scalar inferences occur systematically and freely in embedded positions. We present
Geurts, B., Pouscoulous, N.
openaire +5 more sources
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Discrete Mathematics, 1994 AbstractWe survey some recent results on graphs embedded in higher surfaces or general topological spaces.
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Journal of Algebra, 2011 AbstractWe show in this paper that given any reduced, cancellative, torsion-free, atomic monoid, it is possible to construct a possibly non-atomic domain with atomic factorization structure isomorphic to the given monoid. This is significant, since atomic monoids are known to have more freedom in the factorization properties they may possess than ...
Jim Coykendall, Brenda Johnson Mammenga
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Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source