Results 91 to 100 of about 1,158,783 (289)
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
An Optimal Skorokhod Embedding for Diffusions
, 2002 Given a Brownian motion $B_t$ and a general target law $\mu$ (not necessarily centered or even integrable) we show how to construct an embedding of $\mu$ in $B$.
Cox, A. M. G., Hobson, D. G.
core +2 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Evaluating Word Embeddings in Multi-label Classification Using Fine-grained Name Typing
, 2018 Embedding models typically associate each word with a single real-valued vector, representing its different properties. Evaluation methods, therefore, need to analyze the accuracy and completeness of these properties in embeddings.
Kann, Katharina +2 more
core +1 more source
Counterfactual Mean Embeddings
, 2018 Counterfactual inference has become a ubiquitous tool in online advertisement, recommendation systems, medical diagnosis, and econometrics. Accurate modeling of outcome distributions associated with different interventions -- known as counterfactual distributions -- is crucial for the success of these applications.
Muandet, K. +3 more
openaire +4 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
GDRMA: Graph Neural Networks for Document Retrievals With Mean Aggregation
IEEE AccessWith the proliferation of cloud services and high-capacity hard drives, the volume of stored document data is rapidly increasing. Consequently, large-scale document retrieval tasks have been attracting significant attention.
Shigeru Maya
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Fushe yanjiu yu fushe gongyi xuebaoTrichloroacetic acid is a common nonvolatile byproduct of drinking water disinfection and poses carcinogenic risks to the human body. In this study, four types of nano-oxide@microcrystalline-cellulose-based adsorbents (P25@microcrystalline cellulose ...
FU Lili +6 more
doaj +1 more source