Results 81 to 90 of about 555,379 (343)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

Frustratingly Easy Meta-Embedding -- Computing Meta-Embeddings by Averaging Source Word Embeddings [PDF]

open access: yesarXiv, 2018
Creating accurate meta-embeddings from pre-trained source embeddings has received attention lately. Methods based on global and locally-linear transformation and concatenation have shown to produce accurate meta-embeddings. In this paper, we show that the arithmetic mean of two distinct word embedding sets yields a performant meta-embedding that is ...
arxiv  

On embeddings in the sphere [PDF]

open access: yesProceedings of the American Mathematical Society, 2005
13 pages.
openaire   +3 more sources

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls   +9 more
wiley   +1 more source

Thickness Uniformity Dependence on Polymer Viscosity in Silver-Nanowire-Embedded Flexible and Transparent Electrodes

open access: yesApplied Sciences, 2020
We herein report the effect of the viscosity of a prepolymer solution on the thickness uniformity of silver-nanowire-embedded flexible transparent electrodes.
Moonsoo Chae   +6 more
doaj   +1 more source

Identifying and Mitigating Instability in Embeddings of the Degenerate Core [PDF]

open access: yesarXiv, 2022
Are the embeddings of a graph's degenerate core stable? What happens to the embeddings of nodes in the degenerate core as we systematically remove periphery nodes (by repeated peeling off $k$-cores)? We discover three patterns w.r.t. instability in degenerate-core embeddings across a variety of popular graph embedding algorithms and datasets.
arxiv  

Embedding of Categories [PDF]

open access: yesProceedings of the American Mathematical Society, 1973
In this paper we generalize the notion of exact functor to an arbitrary category and show that every small category has a full embedding into a category of all set-valued functors on some small category. The notion of exact is such that this result generalizes the author’s exact embedding of regular categories and, indeed, Mitchell’s embedding of ...
openaire   +2 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

Hash Embeddings for Efficient Word Representations [PDF]

open access: yesarXiv, 2017
We present hash embeddings, an efficient method for representing words in a continuous vector form. A hash embedding may be seen as an interpolation between a standard word embedding and a word embedding created using a random hash function (the hashing trick).
arxiv  

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