Results 81 to 90 of about 1,295,202 (338)

Categories of embeddings

[1988] Proceedings. Third Annual Information Symposium on Logic in Computer Science, 1989
AbstractWe present a categorical generalisation of the notion of domains, which is closed under (suitable) exponentiation. The goal was originally to generalise Girard's model of polymorphism to Fω. If we specialise this notion in the poset case, we get new cartesian closed categories of domains.
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Embedding of Categories [PDF]

Proceedings of the American Mathematical Society, 1973
In this paper we generalize the notion of exact functor to an arbitrary category and show that every small category has a full embedding into a category of all set-valued functors on some small category. The notion of exact is such that this result generalizes the author’s exact embedding of regular categories and, indeed, Mitchell’s embedding of ...
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The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

A Unified Approach to Attractor Reconstruction

, 2006
In the analysis of complex, nonlinear time series, scientists in a variety of disciplines have relied on a time delayed embedding of their data, i.e. attractor reconstruction.
Jonathan Nichols, Kantz H., Linda Moniz, Louis M. Pecora, Middleton David, Press W. H., Thomas L. Carroll   +6 more
core   +1 more source

Extended Factorization Machines for Sequential Recommendation

IEEE Access, 2020
Users' historical activities are usually contained in real-life sequential recommendation systems to predict their future behaviors. In this situation, traditional Factorization Machines (FMs) approaches may be not suitable.
Nuan Wen, Fang Zhang
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Intervals in Generalized Effect Algebras and their Sub-generalized Effect Algebras

Acta Polytechnica, 2013
We consider subsets G of a generalized effect algebra E with 0∈G and such that every interval [0, q]G = [0, q]E ∩ G of G (q ∈ G , q ≠ 0) is a sub-effect algebra of the effect algebra [0, q]E.
Zdenka Riečanová, Michal Zajac
doaj  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

On Embeddings in Cycles

Information and Computation, 1995
AbstractWe prove exact results on dilations in cycles for important parallel computer interconnection networks such as complete trees, hypercubes, and 2- and 3- dimensional meshes. Moreover, we show that trees, X-trees, n-dimensional meshes, pyramids, and trees of meshes have the same dilations both in the path and in the cycle.
Ondrej Sýkora, Vladimír Müller, Juraj Hromkovic, Imrich Vrťo   +3 more
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