Results 81 to 90 of about 1,397,905 (314)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Universal Scaling of Thin Current Sheets

Geophysical Research Letters, 2020
Thin current sheets (TCSs) with thicknesses about ion Larmor radii are widespread in space. It is important to describe their equilibrium structure allowing them to store and then explosively release the accumulated free energy.
L. M. Zelenyi, H. V. Malova, E. E. Grigorenko, V. Yu Popov, E. M. Dubinin   +4 more
doaj   +1 more source

Nearest Embedded and Embedding Self-Nested Trees [PDF]

Algorithms, 2019
Self-nested trees present a systematic form of redundancy in their subtrees and thus achieve optimal compression rates by directed acrylic graph (DAG) compression. A method for quantifying the degree of self-similarity of plants through self-nested trees was introduced by Godin and Ferraro in 2010.
openaire   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CORE: A knowledge graph entity type prediction method via complex space regression and embedding [PDF]

, 2022
Xiou Ge, Yun-Cheng Wang, Bin Wang, C.‐C. Jay Kuo   +3 more
openalex   +1 more source

An Optimal Skorokhod Embedding for Diffusions

, 2002
Given a Brownian motion $B_t$ and a general target law $\mu$ (not necessarily centered or even integrable) we show how to construct an embedding of $\mu$ in $B$.
Cox, A. M. G., Hobson, D. G.
core   +2 more sources

Some embeddings related to C^*-embeddings [PDF]

Journal of the Australian Mathematical Society. Series A. Pure Mathematics and Statistics, 1988
AbstractA space S is R*-embedded (G*-embedded) in a space X if two disjoint regular closed sets (closure disjoint open sets) of S are contained in disjoint regular closed sets (extended to closure disjoint open sets) of X. A space S is R-extendable to a space X if any regular closed set of S can be extended to a regular closed set of X.
openaire   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

GDRMA: Graph Neural Networks for Document Retrievals With Mean Aggregation

IEEE Access
With the proliferation of cloud services and high-capacity hard drives, the volume of stored document data is rapidly increasing. Consequently, large-scale document retrieval tasks have been attracting significant attention.
Shigeru Maya
doaj   +1 more source