Results 91 to 100 of about 15,432 (298)

Video observations of dynamic embedment during pipelaying in soft clay

, 2009
The as-laid embedment of a pipeline is an important parameter that affects many aspects of pipeline design. Offshore pipelaying is a dynamic process that causes pipelines to embed deeper than predicted based on static penetration models.
M. F. Randolph, D. J. White, Z. J. Westgate, White, D.J., Randolph, M.F., Westgate, Z.J.   +5 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Predicting the as-laid embedment of surface-laid pipelines and cables in sand wave regions

, 2023
Predicting the as-laid embedment of surface-laid pipelines and cables is important for estimating their in-service response. To date, design approaches have only considered flat seabed conditions.
Denis, Raphael, Hou, Zhechen, Delvosal, Pierre, Ballard, Jean Christophe, Bransby, Fraser, Low, Han Eng, Watson, Phil, White, David   +7 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Mathematical Model for Prediction the Embedment Depth of the Contiguous Piles Used in the Interchange of Zakho Entrance

Polytechnic Journal, 2019
Determination of the depths of the embedment of contiguous piles requires extensive soil investigation to obtain the soil physical parameters. In addition, a large number of such piles involved in restricted access projects make that depth an essential ...
Najdat S. Akrawi, Shimal A. Ahmed
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Field observations of as-laid pipeline embedment in carbonate sediments

, 2012
Reliable prediction of the embedment of untrenched subsea pipelines is of increasing importance as hydrocarbon developments progress into deeper waters, located further from shore.
White, D.J., Randolph, M.F., Westgate, Z.J.   +2 more
core   +1 more source

Embedded monopoles

Physics Letters B, 2002
Using the embedded defect method, we classify the possible embeddings of a 't Hooft-Polyakov monopole in a general gauge theory. We then discuss some similarities with embedded vortices and relate our results to fundamental monopoles.
openaire   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Visualization of Flap Length Effects on the Keying Process of Plate Anchors in Transparent Soil

Journal of Marine Science and Engineering
Suction embedded plate anchors (SEPLAs) are widely used in offshore engineering, but their keying process is often accompanied by embedment loss, which reduces the holding capacity.
Chunhui Zhang, Xiaoming Zheng, Wenlong Zhang, Bowei Zhang, Zirong Liu   +4 more
doaj   +1 more source