Results 81 to 90 of about 1,136 (216)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Experimental Investigation of Full Hole Embedment Behavior of Bamboo Scrimber with Dowel-Type Fasteners

Buildings
A comprehensive understanding of the embedment behavior is of great importance in the design of contemporary bamboo constructions with connections utilizing dowel-type fasteners.
Yanyan Liu, Xiaoyu Huang, Siyuan Tang
doaj   +1 more source

Digraph embedding

Discrete Mathematics, 2001
The author studies the problem of upward embedding on the round sphere and gives a characterization of all spherical digraphs.
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Visualization of Flap Length Effects on the Keying Process of Plate Anchors in Transparent Soil

Journal of Marine Science and Engineering
Suction embedded plate anchors (SEPLAs) are widely used in offshore engineering, but their keying process is often accompanied by embedment loss, which reduces the holding capacity.
Chunhui Zhang, Xiaoming Zheng, Wenlong Zhang, Bowei Zhang, Zirong Liu   +4 more
doaj   +1 more source

Experimental Study on the Seismic Performance of Socket Bridge Piers

Advances in Civil Engineering, 2020
In order to accelerate the construction of bridge substructure, a socket joint construction that does not require interfaces roughening between the precast columns and the reserved cavity of the precast foundation is raised in this paper.
Yan Han, Jiawen Dong, Longlong Wang
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Embedded Agency

CoRR, 2019
Traditional models of rational action treat the agent as though it is cleanly separated from its environment, and can act on that environment from the outside. Such agents have a known functional relationship with their environment, can model their environment in every detail, and do not need to reason about themselves or their internal parts.
Abram Demski, Scott Garrabrant
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Small-displacement behavior of offshore wind power monopiles subjected to static lateral loading

Yantu gongcheng xuebao
The centrifuge tests and numerical simulations are carried out to explore the small-displacement behavior of 9 m-diameter offshore wind power large-scale monopiles with various embedment depths. The results show that as the embedment depth increases, the
WANG Wei 1 , ZHANG Zitao 2 , YU Guangming 1, ZHANG Xuedong 2, ZHANG Zechao 1, SONG Jianzheng 2, ZHANG Zheng 2
doaj   +1 more source