Results 61 to 70 of about 1,405,584 (307)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Geotechnics, 2023 One common method of estimating emax and emin for mixtures of sand and silt requires that the values of several empirical constants be determined. These empirical constants are the filling coefficients, a, and embedment coefficients, b, which can be ...
Carmine P. Polito
doaj +1 more source
ACM Transactions on Graphics, 2019 Tutte embedding is one of the most common building blocks in geometry processing algorithms due to its simplicity and provable guarantees. Although provably correct in infinite precision arithmetic, it fails in challenging cases when implemented using floating point arithmetic, largely due to the induced exponential area changes.
Hanxiao Shen +3 more
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Failure Surface Morphology and Uplift Bearing Capacity Calculation of Soil Surrounding Glass Fiber-Reinforced Plastic Screw Anchors [PDF]
长江科学院院报[Objective] As a new type of support anchor, the Glass Fiber-Reinforced Plastic (GFRP) screw anchor is increasingly used in engineering practice due to its simple construction, light weight, high strength, corrosion resistance, and cost-effectiveness ...
ZOU Wei-lie, HAN Yue-huan, WANG Xie-qun, HAN Zhong
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effect of Thermal Modification of Spruce Wood on Nails Embedment Strength [PDF]
Pro Ligno, 2018 Nails represent the easiest and most common method to connect timber members, but, since joints and connections frequently represent the weakest points in timber structures, they need special attention.
Mirko KARIZ +2 more
doaj
Postgraduate Medical Journal, 1982 Abstract A case of an embedded fingernail is reported. The increased curvature of the nail plates is considered aetiologically important. Treatment was by the method first described by Winograd for an embedded toenail.
N, Eke, K, Little
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source