Results 51 to 60 of about 1,136 (216)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
We present a discussion of embedded vortices in general Yang-Mills theories. The origin of a family structure of solutions is shown to be group theoretic in nature and a procedure for its determination is developed. Vortex stability can be quantified into three types: Abelian topological stability, non-Abelian topological stability, and dynamical ...
Lepora, Nathan F., Davis, Anne-Christine
openaire +2 more sources
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
This project considers the efficacy and scalability of embedded librarianship initiatives within the City University of New York (CUNY) library system and presents findings of an original research study conducted in 2015.
Nora Almeida, Julia Pollack
doaj +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Embedment properties are vital to timber structural designs, and many types of wood-based structural panels have been developed for diverse uses. Comprehensive and systematic studies regarding the embedment properties of wood-based structural panels are ...
Ryutaro Sudo +2 more
doaj +1 more source
Tutte embedding is one of the most common building blocks in geometry processing algorithms due to its simplicity and provable guarantees. Although provably correct in infinite precision arithmetic, it fails in challenging cases when implemented using floating point arithmetic, largely due to the induced exponential area changes.
Hanxiao Shen +3 more
openaire +1 more source
Phosphoinositides and inositol phosphates as molecular glues
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Effect of Thermal Modification of Spruce Wood on Nails Embedment Strength [PDF]
Nails represent the easiest and most common method to connect timber members, but, since joints and connections frequently represent the weakest points in timber structures, they need special attention.
Mirko KARIZ +2 more
doaj

