Results 121 to 130 of about 100,878 (217)

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

Morphogen Gradients as Drivers of Mosaicism During Early Human Development. [PDF]

Bioessays
Acebrón SP, Hattemer J, Rausch T, De Jaime-Soguero A.   +3 more
europepmc   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

From the Understanding of Maternal Molecules and Mechanisms to Predicting Embryonic Development. [PDF]

Reprod Med Biol
Wei Y, Inoue A, Miyamoto K.
europepmc   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Vitrification-warming delays preimplantation development and impairs mitochondrial function and cytoplasmic lattices integrity in mouse embryos. [PDF]

iScience
Barroso MT, Rodriguez Muñoz JA, Sjöström V, Dindini K, Zhao J, Rodriguez-Wallberg KA, Reyes Palomares A.   +6 more
europepmc   +1 more source

tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans. [PDF]

Nat Commun
Galambos NS, Crocker OJ, Schneider BK, Allerton KS, Gross KE, Schneider AE, Lynch J, Yukselen O, Kucukural A, Conine CC.   +9 more
europepmc   +1 more source

Imaging and Linking Spatial Magnetic Nanoparticle Distribution to Microbead Torques Using Soft X‐Ray Laminography

Advanced Physics Research, EarlyView.
Nanoscale 3D imaging of superparamagnetic microbeads via soft X‐ray laminography reveals the structural origin of the observed torques in cell movement experiments. These microbeads are found to have an uneven distribution of magnetic magnetite nanoparticles.
Findan Block, Finn Klingbeil, Dennis Seidler, Christine Arndt, Sandra Sindt, Katharina Witte, Benjamin Watts, Jörg Raabe, Christine Selhuber‐Unkel, Jeffrey McCord   +9 more
wiley   +1 more source

How ATP-Dependent Chromatin Remodeling Complexes Regulate Vertebrate Embryonic Development. [PDF]

Int J Mol Sci
Wang H, Anwaier G, Bai S, Liao L, Wang Y, Li S.   +5 more
europepmc   +1 more source

A perspective from the Mesozoic: Evolutionary changes of the mammalian skull and their influence on feeding efficiency and high‐frequency hearing

The Anatomical Record, EarlyView.
Abstract The complex evolutionary history behind modern mammalian chewing performance and hearing function is a result of several changes in the entire skeletomuscular system of the skull and lower jaw. Lately, exciting multifunctional 3D analytical methods and kinematic simulations of feeding functions in both modern and fossil mammals and their ...
Julia A. Schultz
wiley   +1 more source