Eye &ENT Research, Volume 2, Issue 2, Page 104-115, June 2025.Abstract Due to the limited regenerative capacity in adult mammals, the loss of vestibular hair cells (HCs) leads to balance disorders. In this study, we chronologically reprogrammed adult vestibular supporting cells (SCs) via bimodal regulation of Notch signaling, mimicking dynamic changes in Notch signaling during inner ear development. We found that
Shan Zeng +5 more
wiley +1 more source
Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells [PDF]
, 2002 In the vertebrate peripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1 are required for sensory and autonomic neurogenesis, respectively.
Anderson, David J. +3 more
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Leptodactylus pentadactylus [PDF]
, 2012 Number of Pages: 48Integrative BiologyGeological ...
de Sá, Rafael O. +2 more
core +1 more source
Development, Growth &Differentiation, Volume 67, Issue 5, Page 245-269, June 2025.Transcriptome analysis of pou5f3‐regulated genes in zebrafish embryos showed that competence to pou5f3 regulation changes significantly before and after the end of epiboly. The target genes encoded a diverse array of proteins, including transcriptional regulators and signaling molecules.
Masaaki Ikeda +6 more
wiley +1 more source
Pattern generating role for motoneurons in a rythmically active neuronal network [PDF]
, 1998 The role of motoneurons in central motor pattern generation was investigated in the feeding system of the pond snail Lymnaea stagnalis, an important invertebrate model of behavioral rhythm generation.
Benjamin, Paul R +2 more
core +2 more sources
Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms [PDF]
, 2015 Current limitations in technology have prevented an extensive analysis of the connections among neurons, particularly within nonmammalian organisms. We developed a transsynaptic viral tracer originally for use in mice, and then tested its utility in a ...
Baskerville A +21 more
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Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus) : a phylogenetic and population-based comparison [PDF]
, 2017 Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution.
Clark, Bryan W. +9 more
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miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential. [PDF]
, 2018 We have shown that antagomiR inhibition of miRNA miR-21 and miR-196b activity is sufficient to ablate MLL-AF9 leukemia stem cells (LSC) in vivo. Here, we used an shRNA screening approach to mimic miRNA activity on experimentally verified miR-196b targets
Aronow, Bruce J. +15 more
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Background:The Next Generation (NexGen) of Risk Assessment effort is a multi-year collaboration among several organizations evaluating new, potentially more efficient molecular, computational, and systems biology approaches to risk assessment.
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Relations of environmental contaminants, algal toxins, and diet with the reproductive success of American alligators on Florida Lakes [PDF]
, 2001 (113 page ...
Arnold, Beverly S. +3 more
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