Results 41 to 50 of about 10,671 (140)
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Heart Regeneration and Repair: Molecular Mechanism and Therapeutic Targets
MedComm, Volume 6, Issue 10, October 2025.Regarding the general picture of heart regeneration therapy, it encompasses exogenous cell therapy, endogenous medications, metabolism, interventions in gene pathways, as well as the therapeutic strategies in the burgeoning interdisciplinary field of medicine and engineering in recent years.
Mingchuan Liu +9 more
wiley +1 more source
Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors [PDF]
, 2004 The Notch and fibroblast growth factor (FGF) pathways both regulate cell fate specification during mammalian neural development. We have shown previously that Notch1 activation in the murine forebrain promotes radial glial identity. This result, together
Fishell, Gord +5 more
core +2 more sources
The Interplay of Ontogeny and Phylogeny at the Transcriptome Level of the Tetrapod Heart
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 344, Issue 6, Page 325-340, September 2025.The main stages of development during which species‐specific heart anatomy is determined in the ontogeny of representative tetrapods. Transcriptomic similarity is expected earlier in development before heart anatomy diverges. ABSTRACT The tetrapod heart is characterized by three chambers in amphibians and non‐avian reptiles, as opposed to four in birds,
G. A. Cordero +10 more
wiley +1 more source
Generation of a stable packaging cell line producing high-titer PPT-deleted integration-deficient lentiviral vectors [PDF]
, 2015 The risk of insertional mutagenesis inherent to all integrating exogenous expression cassettes was the impetus for the development of various integration-defective lentiviral vector (IDLV) systems.
Hu, Peirong +4 more
core +4 more sources
Zebrafish as a Versatile Model Organism: From Tanks to Treatment
MedComm – Future Medicine, Volume 4, Issue 3, September 2025.The zebrafish, with its optical transparency and genetic tractability, serves as a versatile in vivo platform for biomedical research. This review underscores its significance in modeling a wide spectrum of human diseases—from cancer to metabolic disorders—and in leveraging cutting‐edge technologies like CRISPR and TALENs.
Rupali Srivastava +9 more
wiley +1 more source
Biting into the Genome to Phenome Map: Developmental Genetic Modularity of Cichlid Fish Dentitions [PDF]
, 2016 Within vertebrates, teleost fishes provide a rich evolutionary context for studying the mechanisms of dental divergence because of the numerous axes along which their teeth have diverged phenotypically and presumably developmentally.
Fraser, G.J., Hulsey, C.D., Meyer, A.
core +1 more source
Developmental Dynamics, Volume 254, Issue 8, Page 887-901, August 2025.Abstract Homology in vertebrate body plans is traditionally ascribed to the high‐level conservation of regulatory components within the genetic programs governing them, particularly during the “phylotypic stage.” However, advancements in embryology and molecular phylogeny have unveiled the dynamic nature of gene repertoires responsible for early ...
Shigehiro Kuraku
wiley +1 more source
Zebrafish in the sea of mineral (iron, zinc, and copper) metabolism [PDF]
, 2014 Iron, copper, zinc, and eight other minerals are classified as essential trace elements because they present in minute in vivo quantities and are essential for life.
Fudi Wang, Lu Zhao, Zhidan Xia
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The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source