Organ‐Specific Histopathological Effects of Prenatal Alcohol Exposure: A Narrative Review
Congenital Anomalies, Volume 66, Issue 1, January/December 2026.ABSTRACT The role of alcohol‐induced epigenetic modifications that predispose the fetus to metabolic dysregulation, increased susceptibility to future substance use, and long‐term behavioral and cognitive impairments has received increasing attention.
Rana Nur Gursu +2 more
wiley +1 more source
Identification of T-cell receptor a-chain genes in the chicken [PDF]
, 1994 T-cell receptor (TCR) -chain (TCR) and ß-chain (TCRß) genes are well characterized in mammals, while only TCRß genes have been identified in other vertebrates. To identify avian TCR genes, we used monoclonal anti-CD3 antibodies to isolate chicken TCR for
Aebersold, Ruedi +7 more
core
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.ABSTRACT The accelerating integration of rare earth elements (REEs) in advanced technologies has generated rising concern over human exposure and the attendant toxicological risks. This review presents an up‐to‐date synthesis of current evidence on REE toxicity across multiple exposure pathways, including inhalation, ingestion and occupational contact,
Jose L. Domingo
wiley +1 more source
Human pluripotent stem cells as tools for high-throughput and high-content screening in drug discovery [PDF]
, 2015 A significant bottleneck in drug discovery is the lack of suitable models for sensitive, reliable, and rapid assessment of lead molecules in preclinical stages of drug discovery.
Allison, T.F. +4 more
core +1 more source
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 343, Issue 10, Page 1191-1204, December 2025.ABSTRACT Peroxisome proliferator‐activated receptors (PPAR) are master transcriptional regulators that maintain metabolic homeostasis in vertebrates. Amphibians are often exposed to endocrine disrupting compounds (EDCs) that could dysregulate lipid metabolism.
Anna Bushong +3 more
wiley +1 more source
Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - a fundamental feature of vertebrate genomes [PDF]
, 2007 A large-scale enhancer detection screen was performed in the zebrafish using a retroviral vector carrying a basal promoter and a fluorescent protein reporter cassette. Analysis of insertional hotspots uncovered areas around developmental regulatory genes
Kikuta, Hiroshi +4 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse [PDF]
, 2011 The cytoplasmic dynein complex is fundamentally important to all eukaryotic cells for transporting a variety of essential cargoes along microtubules within the cell. This complex also plays more specialized roles in neurons.
AlQatari, Mona +9 more
core +1 more source
Functional rescue of REP1 following treatment with PTC124 and novel derivative PTC-414 in human choroideremia fibroblasts and the nonsense-mediated zebrafish model [PDF]
, 2016 Choroideremia (CHM) is an X-linked chorioretinal dystrophy that is caused by mutations within a single gene, CHM Currently no effective treatment exists for these patients.
Coffey, P +9 more
core +1 more source