Results 61 to 70 of about 161,152 (304)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The effectiveness of human SAGE medium compared to other conventional culture media on the ovine early embryonic development, in vitro [PDF]
Iraqi Journal of Veterinary SciencesDeveloping an optimal in vitro embryo culture medium with high blastocyst rates and good-quality embryos remains challenging and controversial, as most culture media directly impact mammalian embryonic development.
Saif O. Al-Hafedh +2 more
doaj +1 more source
Mammalian preimplantation embryo culture
, 2014 Since the inception of modern embryo culture media over 50 years ago there have been significant developments in culture systems for the mammalian preimplantation embryo.
Gardner, D.K., Lane, M.
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Experimental study of embryo differentiation in angiosperms
Acta Societatis Botanicorum Poloniae, 2014 By comparison of peony and lotus embryos in in vitro culture we established differences in their morphogenetic potential. We traced in peony embryo culture: embryogenesis, embryoidogenesis, organogenesis and histogenesis, whereas the lotus embryo ...
T. B. Batygina, V. E. Vasilyeva
doaj +1 more source
Culture systems for the human embryo
, 2012 Embryo culture is often mistaken for a relatively simple procedure. In reality, it is a complex task, requiring proactive quality control and quality assurance programs, together with a high level of training for embryologists.
Michelle Lane +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2017 Creation of pure lines is one of the basic requirements in plant breeding. Doubled haploid (DH) lines are completely homozygous lines and anther culture is an efficient method for DH line production.
Ali Akbar Heidari +4 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A Novel Shell-less Culture System for Chick Embryos Using a Plastic Film as Culture Vessels
The Journal of Poultry Science, 2014 The development of shell-less culture methods for bird embryos with high hatchability would be useful for the efficient generation of transgenic chickens, embryo manipulations, tissue engineering, and basic studies in regenerative medicine.
Yutaka Tahara, Katsuya Obara
doaj +1 more source