Results 51 to 60 of about 161,152 (304)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The effect of overnight culture after thawing of D3 cleavage-stage embryos on clinical pregnancy outcomes: focus on embryo development to day 4

Frontiers in Endocrinology
ObjectiveThis study aims to investigate the impact of day-3 (D3) cleavage-stage embryo thawing with immediate transfer versus thawing and overnight culture before transfer on clinical outcomes.
Liuping Lan, Xiang Li, Bowen Luo, Weiwu Liu, Lingling Zhu, Juguang Zhang, Jian Wen, Keng Feng, Derong Li, Feifei Lei, Guosheng Deng, Yudi Luo, Zengyu Yang   +12 more
doaj   +1 more source

Impact of TGF-β and ERK1/2 inhibition on preimplantation embryo development and quality [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Preimplantation embryo culture is a critical phase in assisted reproductive technologies. The use of small molecules to modulate signaling pathways has emerged as a strategy to improve embryo viability.
Faezah Mohammadi Ghazani, Fatemeh Shirvanizadeh, Seyedeh-Nafiseh Hassani, Azam Dalman, Nahid Nasiri, Maryam Zarei, Saman Maroufizadeh, Poopak Eftekhari Yazdi   +7 more
doaj   +1 more source

Homozygous Transgenic Barley (Hordeum vulgare L.) Plants by Anther Culture

Plants, 2020
Production of homozygous lines derived from transgenic plants is one of the important steps for phenotyping and genotyping transgenic progeny. The selection of homozygous plants is a tedious process that can be significantly shortened by androgenesis ...
Ludmila Ohnoutková, Tomáš Vlčko
doaj   +1 more source

Culture and quality control of embryos [PDF]

Human Reproduction, 1998
Improvement of embryo quality during in-vitro culture can be achieved by understanding and controlling the requirements of gametes and embryos. The most obvious route is to alter culture media, but standardization could be influenced by diverse environmental factors.
J, Cohen, A, Gilligan, S, Willadsen
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Establishment of a Single-Oocyte Culture System for Pigs and Its Validation Using Curcumin as a Model Antioxidant for Oocyte Maturation

Animals
Since individual embryos cannot be evaluated in group culture, establishing a single culture from in vitro maturation to in vitro culture may provide new insights into oocyte and embryo quality.
Zhao Namula, Takeshige Otoi, Theerawat Tharasanit, Kaywalee Chatdarong, Megumi Nagahara, Oky Setyo Widodo, Aya Nakai, Suong Thi Nguyen, Yuichiro Nakayama, Maki Hirata, Fuminori Tanihara   +10 more
doaj   +1 more source

Regulating Reprogenetics: Strategic Sacralisation and Semantic Message [PDF]

, 2007
This paper forms part of the feminist critique of the regulatory consequences of biomedicine's systematic exclusion of the role of women's bodies in the development ofreprogenetic technologies.
Mackenzie, Robin, Robin Mackenzie
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The Emergence of H7N7 Highly Pathogenic Avian Influenza Virus from Low Pathogenicity Avian Influenza Virus Using an in ovo Embryo Culture Model

Viruses, 2020
Outbreaks of highly pathogenic avian influenza virus (HPAIV) often result in the infection of millions of poultry, causing up to 100% mortality. HPAIV has been shown to emerge from low pathogenicity avian influenza virus (LPAIV) in field outbreaks ...
Amanda H. Seekings, Wendy A. Howard, Alejandro Nuñéz, Marek J. Slomka, Ashley C. Banyard, Daniel Hicks, Richard J. Ellis, Javier Nuñéz-García, Lorian C. Hartgroves, Wendy S. Barclay, Jill Banks, Ian H. Brown   +11 more
doaj   +1 more source