Results 101 to 110 of about 573,263 (362)

Birth of India’s first cloned cattle and analysis of its health and reproduction status: A case study

Scientific Reports
Somatic cell nuclear transfer (SCNT) allows the multiplication of elite livestock and conservation of endangered species. However, restrictions on cow slaughter limit the access to oocytes for SCNT applications in Indian cattle breeds.
Naresh L. Selokar, Manoj K. Singh, Gaurav Tripathi, Kartikey Patel, Ranjeet Verma, Priyanka Singh, Ajay Aswal, Manmohan Singh Chauhan   +7 more
doaj   +1 more source

Bisphenol P induces ovarian dysfunction by directly targeting PTGS2 and disrupting steroid hormone synthesis

Ecotoxicology and Environmental Safety
Emerging evidence suggests structural analogues of bisphenol A (BPA), including the increasingly used substitute bisphenol P (BPP), pose substantial reproductive risks. However, BPP's ovarian toxicity remains uncharacterized.
Dingmei Qin, Zijian Ma, Zhipeng Lin, Lei Wang, Jian Wang, Xing Zhang, Xiaoqing Wu, Jingya Li, Shujun Sun, Shangrong Zhang   +9 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Spatial mechanisms of gene regulation in metazoan embryos [PDF]

, 1991
The basic characteristics of embryonic process throughout Metazoa are considered with focus on those aspects that provide insight into how cell specification occurs in the initial stages of development.
Davidson, Eric H.
core  

Human embryos cultured in vitro to 14 days [PDF]

, 2017
We know a great deal about the development of the mammalian embryo until the time that the blastocyst implants into the uterus. With model organisms such as the mouse, we have also developed a considerable understanding of development immediately around ...
Morris, Samantha A.
core   +2 more sources

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

BPP disrupts spermatogenesis via mitochondrial-ER stress-mediated autophagic flux blockade in mice

Ecotoxicology and Environmental Safety
Endocrine-disrupting chemicals (EDCs), particularly bisphenol A (BPA) and its analogs, have been extensively linked to male reproductive toxicity. However, the biological effects of bisphenol P (BPP), an increasingly used BPA substitute, remain poorly ...
Shangrong Zhang, Dingmei Qin, Zhipeng Lin, Siyu Wang, Lei Wang, Jian Wang, Xing Zhang, Shujun Sun, Qing Ding, Xiangyu Chen, Jingya Li, Jiayu Liu, Zijian Ma, Xiaoqing Wu, Yong Liu   +14 more
doaj   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

YOLOv8-BaitScan: A Lightweight and Robust Framework for Accurate Bait Detection and Counting in Aquaculture

Fishes
Excessive bait wastage is a major issue in aquaculture, leading to higher farming costs, economic losses, and water pollution caused by bacterial growth from unremoved residual bait.
Jian Li, Zehao Zhang, Yanan Wei, Tan Wang   +3 more
doaj   +1 more source