Results 31 to 40 of about 254,276 (267)

Machine learning and bioinformatics framework integration reveal potential characteristic genes related to immune cell infiltration in preeclampsia

Frontiers in Physiology, 2023
Introduction: Preeclampsia is a disease that affects both the mother and child, with serious consequences. Screening the characteristic genes of preeclampsia and studying the placental immune microenvironment are expected to explore specific methods for ...
Lilian Bai, Yanyan Guo, Junxing Gong, Yuchen Li, Hefeng Huang, Hefeng Huang, Hefeng Huang, Hefeng Huang, Yicong Meng, Xinmei Liu   +9 more
doaj   +1 more source

Development of Cultured Quail Embryos

Poultry Science, 1983
Japanese quail embryos were cultured by a plastic wrap technique after 2.5 days of normal incubation, and their development was investigated. Mean survival time was 13 days (2.5 days of preincubation plus 10.5 days of experimental culture). Mean morphological stage shown by the cultured embryos was Stage 28 of Zacchei (1961) (corresponding to 11 days ...
T, Ono, N, Wakasugi
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Human pre-implantation embryo development

Development, 2012
Understanding human pre-implantation development has important implications for assisted reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies. Owing to limited resources, the cellular and molecular mechanisms governing this early stage of human development are poorly understood.
Niakan, KK, Han, JN, Pedersen, RA, Simon, C, Pera, RAR   +4 more
openaire   +5 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cyclic AMP mediates ovine cumulus–oocyte gap junctional function via balancing connexin 43 expression and phosphorylation

Endocrine Connections, 2023
Gap junction channels in cumulus–oocyte complexes (COCs) enable the transmission and communication of small molecular signals between adjacent cells, such as cAMP.
Yufen Zhao, Erge Namei, Bingxue Yang, Xiangnan Bao, Wei Sun, Gerile Subudeng, Guifang Cao, Haijun Li, Gui Wang   +8 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Integrative analysis of circulating microRNAs and the placental transcriptome in recurrent pregnancy loss

Frontiers in Physiology, 2022
Recurrent pregnancy loss (RPL) is a major type of pathological pregnancy that still lacks reliable early diagnosis and effective treatment. The placenta is critical to fetal development and pregnancy success because it participates in critical processes ...
Naixin Xu, Naixin Xu, Xuanyou Zhou, Xuanyou Zhou, Weihui Shi, Weihui Shi, Mujin Ye, Mujin Ye, Xianling Cao, Songchang Chen, Songchang Chen, Songchang Chen, Chenming Xu, Chenming Xu, Chenming Xu   +14 more
doaj   +1 more source

Neuron development in human embryos [PDF]

Science, 2016
Human Biology Mammalian fertility depends on the secretion of gonadotropin-releasing hormone (GnRH) from a population of specialized neurons residing in the hypothalamus. During embryogenesis, these neurons develop at the olfactory placodes, and they subsequently migrate to the brain.
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source