Results 1 to 10 of about 108,223 (347)

RO8191, a new compound for initiating embryo implantation in mice [PDF]

Scientific Reports
During early pregnancy in mice, leukemia inhibitory factor (LIF) regulates embryo implantation by activating the JAK/STAT3 signaling pathway. The STAT3 pathway has been recognized to play a critical role in embryo implantation; however, it remains ...
Junlan Shu, Jumpei Terakawa, Sota Takikawa, Satoko Osuka, Ayako Muraoka, Jiali Ruan, Atsuo Iida, Junya Ito, Eiichi Hondo   +8 more
doaj   +3 more sources

Role of circadian clock in female embryo implantation [PDF]

Frontiers in Cell and Developmental Biology
Accumulating evidence indicates that circadian rhythm disruption can exert an impact on female reproductive function. In the context of female reproduction, the success of embryo implantation is of utmost significance as it is an essential process for ...
Yukai Zhou, Yukai Zhou, Xiaodie He, Xiaodie He, Zhenxin Chen, Zhenxin Chen, Yucong Gou, Kaixin Zhou, Jinrong Huang, Mei Chen, Jin Hong, Lei Gao, Lei Gao   +12 more
doaj   +2 more sources

Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos [PDF]

, 2012
Background The aetiology of recurrent miscarriage (RM) remains largely unexplained. Women with RM have a shorter time to pregnancy interval than normally fertile women, which may be due to more frequent implantation of non-viable embryos.
AJ Wilcox, AM Musters, Annemieke Kavelaars, B Gellersen, Birgit Gellersen, Charlotte H. E. Weimar, Cobi J. Heijnen, Cornelis B. Lambalk, CW Redman, DK Gardner, E Vanneste, EB Baart, G Teklenburg, G Teklenburg, GM Stirrat, H Carp, HJ Leese, HJ Leese, HM Picton, IC Lakovschek, Jan J. Brosens, JD Aplin, JL Evers, Johanna M. T. de Vreeden-Elbertse, M Bielanska, M Gonzalez, M Salker, N Mansouri-Attia, Nick S. Macklon, NS Macklon, PJ Stokes, R Rai, RM Popovici, S Grewal, S Grewal, S Quenby   +35 more
core   +31 more sources

Cell-cycle machinery is critical in regulating uterine steroid hormone for embryo implantation and development [PDF]

The Journal of Clinical Investigation
Proper embryo implantation is necessary for a successful pregnancy. In this issue of the JCI, Aljubran et al. identified the cell cycle regulatory protein cyclin A2 (CCNA2) as a factor in supporting embryo implantation and embryo development. Endometrial
Francesco J. DeMayo
doaj   +2 more sources

Endometrial stromal cell miR-19b-3p release is reduced during decidualization implying a role in decidual-trophoblast cross-talk

Frontiers in Endocrinology, 2023
IntroductionA healthy pregnancy requires successful blastocyst implantation into an adequately prepared or ‘receptive’ endometrium. Decidualization of uterine endometrial stromal fibroblast cells (hESF) is critical for the establishment of a healthy ...
Ellen Menkhorst, Ellen Menkhorst, Teresa So, Teresa So, Kate Rainczuk, Siena Barton, Siena Barton, Wei Zhou, Wei Zhou, Tracey Edgell, Evdokia Dimitriadis, Evdokia Dimitriadis, Evdokia Dimitriadis   +12 more
doaj   +1 more source

Intrauterine administration of peripheral blood mononuclear cells (PBMCs) improves embryo implantation in mice by regulating local Treg/Th17 cell balance

The Journal of Reproduction and Development, 2021
Immune imbalance of Treg/Th17 cells may contribute to recurrent implantation failure (RIF) during in vitro fertilization and embryo transfer (IVF-ET). In this study, we sought to determine the effect of intrauterine administration of mouse PBMCs prior to
Lei FAN, Menghan SHA, Wei LI, Qingling KANG, Jianli WU, Suhua CHEN, Nan YU   +6 more
doaj   +1 more source

Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Pharmaceuticals, 2021
Infertility is an emerging health issue worldwide, and female infertility is intimately associated with embryo implantation failure. Embryo implantation is an essential process during the initiation of prenatal development.
Hyerin Park, Minkyoung Cho, Yoonju Do, Jang-Kyung Park, Sung-Jin Bae, Jongkil Joo, Ki-Tae Ha   +6 more
doaj   +1 more source

Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice

Genes and Diseases, 2021
Embryo implantation and decidualization are crucial for successful pregnancy, which include multiple genes and signaling pathways, while the precise mechanism regarding embryo implantation and decidualization has yet to be explored.
Wenhao Chen, Qian Zhang, Haibin Wang, Dongmei Tan, Yi Tan   +4 more
doaj   +1 more source

Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

Biomolecules, 2021
Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that plays a critical role in various physiological and pathological processes.
Xi Guo, Hong Yi, Tin Chiu Li, Yu Wang, Huilin Wang, Xiaoyan Chen   +5 more
doaj   +1 more source

microRNAs as A Biomarker to Predict Embryo Quality Assessment in In Vitro Fertilization [PDF]

International Journal of Fertility and Sterility, 2023
Embryo selection for in vitro fertilization (IVF) is an effort to increase the success rate of embryo implantation. Factors influencing the success of embryo implantation include embryo quality, endometrial receptivity, embryo characteristics, and ...
Kresna Mutia, Budi Wiweko, Abinawanto Abinawanto, Astari Dwiranti, Anom Bowolaksono   +4 more
doaj   +1 more source