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Human embryo implantation.

Development, 2023
Embryo implantation in humans is interstitial, meaning the entire conceptus embeds in the endometrium before the placental trophoblast invades beyond the uterine mucosa into the underlying inner myometrium.
Muter J, Lynch VJ, McCoy RC, Brosens JJ.
europepmc   +4 more sources

Single-cell analysis of mouse uterus at the invasion phase of embryo implantation

Cell & Bioscience, 2022
Background Embryo implantation into the uterus is a crucial step for human reproduction. A hypothesis has been proposed that the molecular circuit invented by trophoblasts for invasive embryo implantation during evolution might be misused by cancer cells
Jia-Peng He, Qing Tian, Qiu-Yang Zhu, Ji-Long Liu   +3 more
doaj   +2 more sources

Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

Biomolecules, 2021
Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that plays a critical role in various physiological and pathological processes.
Xi Guo, Hong Yi, Tin Chiu Li, Yu Wang, Huilin Wang, Xiaoyan Chen   +5 more
doaj   +2 more sources

Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Pharmaceuticals, 2021
Infertility is an emerging health issue worldwide, and female infertility is intimately associated with embryo implantation failure. Embryo implantation is an essential process during the initiation of prenatal development.
Hyerin Park, Minkyoung Cho, Yoonju Do, Jang-Kyung Park, Sung-Jin Bae, Jongkil Joo, Ki-Tae Ha   +6 more
doaj   +2 more sources

Role of circadian clock in female embryo implantation [PDF]

Frontiers in Cell and Developmental Biology
Accumulating evidence indicates that circadian rhythm disruption can exert an impact on female reproductive function. In the context of female reproduction, the success of embryo implantation is of utmost significance as it is an essential process for ...
Yukai Zhou, Yukai Zhou, Xiaodie He, Xiaodie He, Zhenxin Chen, Zhenxin Chen, Yucong Gou, Kaixin Zhou, Jinrong Huang, Mei Chen, Jin Hong, Lei Gao, Lei Gao   +12 more
doaj   +2 more sources

The Complicated Effects of Extracellular Vesicles and Their Cargos on Embryo Implantation

Frontiers in Endocrinology, 2021
As a rate-limiting step in pregnancy, embryo implantation is highly dependent on intercellular communication. Extracellular vesicles (EVs) are newly identified to be important in the course of intercellular communication.
Nan-Xing Jiang, Nan-Xing Jiang, Xue-Lian Li, Xue-Lian Li   +3 more
doaj   +2 more sources

Modeling embryo-endometrial interface recapitulating human embryo implantation. [PDF]

Sci Adv
The initiation of human pregnancy is marked by the implantation of an embryo into the uterine environment; however, the underlying mechanisms remain largely elusive.
Shibata S, Endo S, Nagai LAE, H Kobayashi E, Oike A, Kobayashi N, Kobayashi N, Kitamura A, Hori T, Nashimoto Y, Nakato R, Hamada H, Kaji H, Kikutake C, Suyama M, Saito M, Yaegashi N, Okae H, Arima T.   +18 more
europepmc   +2 more sources

Secreted MicroRNA to Predict Embryo Implantation Outcome: From Research to Clinical Diagnostic Application

Frontiers in Cell and Developmental Biology, 2020
Embryo implantation failure is considered a leading cause of infertility and a significant bottleneck for in vitro fertilization (IVF) treatment. Confirmed factors that lead to implantation failure involve unhealthy embryos, unreceptive endometrium, and ...
Wei Zhou, Wei Zhou, Evdokia Dimitriadis, Evdokia Dimitriadis   +3 more
doaj   +2 more sources

Uterine receptivity, embryo attachment, and embryo invasion: Multistep processes in embryo implantation

Reproductive Medicine and Biology, 2019
Background Recurrent implantation failure is a critical issue in IVF‐ET treatment. Successful embryo implantation needs appropriate molecular and cellular communications between embryo and uterus.
Yamato Fukui, Yasushi Hirota, Mitsunori Matsuo, Mona Gebril, Shun Akaeda, Takehiro Hiraoka, Yutaka Osuga   +6 more
doaj   +2 more sources

Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential [PDF]

Frontiers in Endocrinology
IntroductionInfertility is characterized by the failure to conceive after 12 months of unprotected sexual intercourse. In assisted reproduction technologies (ARTs), in-vitro fertilization and embryo transfer (IVF-ET) are pivotal, with the quality of ...
Francesco M. Bulletti, Romualdo Sciorio, Alessandro Conforti, Roberto De Luca, Carlo Bulletti, Antonio Palagiano, Marco Berrettini, Giulia Scaravelli, Roger A. Pierson   +8 more
doaj   +2 more sources