Results 41 to 50 of about 62,103 (297)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell lineage specific distribution of H3K27 trimethylation accumulation in an in vitro model for human implantation

, 2012
Female mammals inactivate one of their two X-chromosomes to compensate for the difference in gene-dosage with males that have just one X-chromosome. X-chromosome inactivation is initiated by the expression of the non-coding RNA Xist, which coats the X ...
Weimar, Charlotte H. E., Weimar, C.H., Heijnen Cobi J., Kuijk Ewart W., Kuijk, E.W., Fauser, B.C., Lopes, S.M.C.D., Bart C J M Fauser, Ewart W Kuijk, Geijsen Niels, Weimar Charlotte H. E., Macklon Nick, Kuijk, Ewart W., Teklenburg, G., Fauser Bart C. J. M., Susana M Chuva de Sousa Lopes, Macklon, N., Teklenburg Gijs, Macklon, Nick, Niels Geijsen, Lopes, S.M., Weimar, C.H.E., Fauser, Bart C. J. M., Teklenburg, Gijs, Geijsen, Niels, Nick Macklon, Geijsen, N., Cobi J Heijnen, Charlotte H E Weimar, Heijnen, Cobi J., Fauser, B.C.J.M., Heijnen, C.J., Chuva de Sousa Lopes Susana M., Chuva de Sousa Lopez, Susana M., Gijs Teklenburg   +34 more
core   +1 more source

Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

Cell Reports, 2021
Summary: At implantation, the embryo establishes contacts with the maternal endometrium. This stage is associated with a high incidence of preclinical pregnancy losses. While the maternal factors underlying uterine receptivity have been investigated, the
Matteo Amitaba Molè, Antonia Weberling, Reinhard Fässler, Alison Campbell, Simon Fishel, Magdalena Zernicka-Goetz   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors

, 2013
Human implantation involves extensive tissue remodeling at the fetal-maternal interface. It is becoming increasingly evident that not only trophoblast, but also decidualizing endometrial stromal cells are inherently motile and invasive, and likely ...
Annemarie Samalecos, Annemarie Samalecos (275635), Anja Wolf (275636), Weimar, C.H., Philipp Velicky, Michelle Kruse (275634), Wolf Anja, Kruse Michelle, Nick S Macklon, Macklon Nick S., Charlotte H. E. Weimar (148304), Nick S. Macklon (148320), Velicky Philipp, Weimar Charlotte H. E., Maren Schwenke, Philipp Velicky (275632), Gellersen Birgit, Schwenke, M., Maren Schwenke (275628), Knöfler Martin, Schwenke Maren, Gellersen, B., Samalecos Annemarie, Wolf, A., Bamberger, A.M., Martin Knöfler, Anja Wolf, Bamberger Ana-Maria, Michelle Kruse, Charlotte H E Weimar, Birgit Gellersen (148307), Velicky, P., Ana-Maria Bamberger, Ana-Maria Bamberger (275637), Kruse, M., Macklon, N.S., Birgit Gellersen, Knofler, M., Samalecos, A., Martin Knöfler (275630)   +39 more
core   +1 more source

Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota

Frontiers in Immunology, 2020
Understanding what happens at the time of embryo implantation has been the subject of significant research. Investigators from many differing fields including maternal fetal medicine, microbiology, genetics, reproductive endocrinology and immunology have
Jonah Bardos, Jonah Bardos, Desiree Fiorentino, Desiree Fiorentino, Ryan E. Longman, Ryan E. Longman, Michael Paidas   +6 more
doaj   +1 more source

Revisiting the Transcriptome Landscape of Pig Embryo Implantation Site at Single-Cell Resolution

Frontiers in Cell and Developmental Biology, 2022
Litter size is one of the most economically important traits in commercial pig farming. It has been estimated that approximately 30% of porcine embryos are lost during the peri-implantation period.
Qing Tian, Jia-Peng He, Can Zhu, Qiu-Yang Zhu, Yu-Gu Li, Ji-Long Liu   +5 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Bovine peripheral blood MSCs chemotax towards inflammation and embryo implantation stimuli

, 2020
Mesenchymal stem cells (MSCs) have a great potential in regenerative medicine because of their multipotential and immunoregulatory capacities, while in early pregnancy they could participate in the immunotolerance of the mother towards the embryo ...
Blanco Murcia, Francisco Javier, Calle, Alexandra, Enric Borràs, Francesc, de la Fuente, Julio, Re, Michela Tatiana, Gutiérrez-Reinoso, Miguel Ángel, Monguió-Tortajada, Marta, Yáñez-Mó, María, Ramírez, Miguel Ángel   +8 more
core   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source