O-GlcNAcylation regulates endometrial decidualization through dual mechanisms: PI3K-AKT axis-mediated phosphorylation and direct modification of FOXO1 [PDF]
Biology DirectBackground Steroid hormone-driven endometrial decidualization involves the differentiation of endometrial stromal cells into decidual cells, which form the decidua for blastocyst implantation.
Qianyi Sun +8 more
doaj +2 more sources
The Regulators of Human Endometrial Stromal Cell Decidualization
Biomolecules, 2022 Several factors are important for implantation and subsequent placentation in the endometrium, including immunity, angiogenesis, extracellular matrix, glucose metabolism, reactive oxidative stress, and hormones.
Hiromi Murata +2 more
exaly +3 more sources
HDAC3 Regulates Transcriptional Networks Governing Decidualization. [PDF]
FASEB JHDAC3 orchestrates transcriptional programs essential for uterine decidualization. Loss of HDAC3 disrupts cytoskeletal organization, metabolic signaling, and oxidative stress responses, impairing stromal cell differentiation and decidualization. These alterations compromise uterine receptivity and result in failed embryo implantation.
Nguyen LTK +5 more
europepmc +2 more sources
Age-Dependent Alterations of Chromosomal Passenger Complex Members During Implantation and Decidualization in the Mouse Uterus. [PDF]
Aging CellAging in females reduces the number of implantation sites and leads to specific, compartment‐dependent changes in components of the chromosomal passenger complex (pIncenp, Aurora B, Survivin, Borealin) during mouse uterine implantation and decidualization.
Golal E, Balci CN, Acar N.
europepmc +2 more sources
HK2-driven histone H3K18 lactylation promotes stromal cell senescence and decidualization deficiency in URSA via CUX1-mediated SASP factor transcription [PDF]
Cellular & Molecular Biology LettersBackground Unexplained recurrent spontaneous abortion (URSA) is characterized by defective endometrial stromal cell decidualization, with cellular senescence emerging as a key contributor.
Xiaoxuan Zhao +6 more
doaj +2 more sources
Aspirin enhances endometrial decidualization markers in vitro among women with and without endometriosis [PDF]
Reproduction and FertilityDecidualization of human endometrial stromal cells (ESCs) precedes the successful implantation of a human embryo. Improper decidualization has been reported in numerous conditions associated with infertility, including endometriosis.
Edward R McClellan +7 more
doaj +2 more sources
Unveiling the Role of Vitamin D/VDR in Promoting Endometrial Decidualization [PDF]
International Journal of EndocrinologyVitamin D’s impact on reproductive health, particularly endometrial receptivity, has attracted significant attention. This study investigated the effects of vitamin D and its receptor (VDR) on decidualization in human endometrial stromal cells (HESCs ...
Jing Guo +4 more
doaj +2 more sources
Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression. [PDF]
, 2012 Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive.
Burghard F. Klapp +11 more
core +30 more sources
Lysophosphatidic acid promotes endometrial decidualization in recurrent implantation failure patients by regulating LPAR6 [PDF]
Frontiers in Cell and Developmental BiologyBackgroundImpaired decidualization is associated with recurrent implantation failure (RIF) and lysophosphatidic acid (LPA) is known to play an important role in decidua formation.
Shanshan Wang +5 more
doaj +2 more sources
Glucose metabolism and endometrium decidualization
Frontiers in EndocrinologyPrior to embryo implantation, the endometrial stromal cells (ESCs) during the menstrual cycle undergo a significant structural and functional transformation known as decidualization to support conception.
Qinling Zhu
exaly +3 more sources