The Regulators of Human Endometrial Stromal Cell Decidualization
Biomolecules, 2022 Several factors are important for implantation and subsequent placentation in the endometrium, including immunity, angiogenesis, extracellular matrix, glucose metabolism, reactive oxidative stress, and hormones.
Hiromi Murata +2 more
exaly +3 more sources
O-GlcNAcylation regulates endometrial decidualization through dual mechanisms: PI3K-AKT axis-mediated phosphorylation and direct modification of FOXO1 [PDF]
Biology DirectBackground Steroid hormone-driven endometrial decidualization involves the differentiation of endometrial stromal cells into decidual cells, which form the decidua for blastocyst implantation.
Qianyi Sun +8 more
doaj +2 more sources
LGR5 as a therapeutic target for decidualization-based endometrial mesenchymal stem cells therapy in thin endometrium [PDF]
Stem Cell Research & TherapyBackground Decidualization of endometrial mesenchymal stem cells (ESCs) is crucial for the implantation of the embryo. Thin endometrium (TE) can impair endometrial receptivity by affecting the decidualization of ESCs.
Kai Chen +6 more
doaj +2 more sources
High incidence of decidualization failure in infertile women
Reproductive Medicine and BiologyPurpose Decidualization is an important event for embryo implantation and successful pregnancy. Impaired decidualization leads to implantation failure and miscarriage. However, it is unclear how often decidualization failure occurs in infertile women. By
Norihiro Sugino +2 more
exaly +2 more sources
Distinct decidualization and senomorphic responses in endometrial vs. menstrual blood stem/stromal cells: implications for reproductive therapies [PDF]
Stem Cell Research & TherapyBackground Decidualization, the process of endometrial stem/stromal cell (EnSCs) differentiation, is essential for embryo implantation and pregnancy maintenance. Menstrual blood-derived stem/stromal cells (MenSCs), although often considered as surrogates
Negar Vanaki +7 more
doaj +2 more sources
HK2-driven histone H3K18 lactylation promotes stromal cell senescence and decidualization deficiency in URSA via CUX1-mediated SASP factor transcription [PDF]
Cellular & Molecular Biology LettersBackground Unexplained recurrent spontaneous abortion (URSA) is characterized by defective endometrial stromal cell decidualization, with cellular senescence emerging as a key contributor.
Xiaoxuan Zhao +6 more
doaj +2 more sources
Unveiling the Role of Vitamin D/VDR in Promoting Endometrial Decidualization [PDF]
International Journal of EndocrinologyVitamin D’s impact on reproductive health, particularly endometrial receptivity, has attracted significant attention. This study investigated the effects of vitamin D and its receptor (VDR) on decidualization in human endometrial stromal cells (HESCs ...
Jing Guo +4 more
doaj +2 more sources
Embryo-derive TNF promotes decidualization via fibroblast activation
eLife, 2023 Decidualization is a process in which endometrial stromal fibroblasts differentiate into specialized secretory decidual cells and essential for the successful establishment of pregnancy.
Si-Ting Chen +9 more
doaj +1 more source
Fertility & Reproduction, 2023 Background and Aims: Endometrial decidualization is a step in establishing and maintaining pregnancy. Senescence was considered to accompany with decidualization.
Song Zhuo
doaj +1 more source
An IGF1-expressing endometrial stromal cell population is associated with human decidualization
BMC Biology, 2022 Background Decidualization refers to the process of transformation of endometrial stromal fibroblast cells into specialized decidual stromal cells that provide a nutritive and immunoprivileged matrix essential for blastocyst implantation and placental ...
Jia-Wei Shi +11 more
doaj +1 more source