Association of thyroid peroxidase antibodies with the rate of first-trimester miscarriage in euthyroid women with unexplained recurrent spontaneous abortion [PDF]
Frontiers in Endocrinology, 2022 BackgroundUnexplained recurrent spontaneous abortion is a serious reproductive problem of unknown etiology. Thyroid peroxidase antibodies (TPO-Ab) may be associated with pregnancy outcomes in unexplained recurrent spontaneous abortion with normal thyroid
Meilan Liu +12 more
doaj +4 more sources
Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion [PDF]
Immunity, Inflammation and Disease, 2021 Introduction Lymphocyte immunotherapy (LIT) is believed to be a viable treatment for unexplained recurrent spontaneous abortion (URSA), but its effect remains controversial.
Sudong Liu, Xiaodong Gu, Ruiqiang Weng
doaj +3 more sources
Temporal changes in cyclinD-CDK4/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion [PDF]
Molecular Medicine, 2022 Background Deficient endometrial decidualization has been associated with URSA. However, the underlying mechanism is poorly understood. This study aimed to investigate the temporal cytokine changes and the involvement of CyclinD-CDK4/6 and CyclinE-CDK2 ...
Zhuo Chang +13 more
doaj +2 more sources
A missense variant in NCF1 is associated with susceptibility to unexplained recurrent spontaneous abortion [PDF]
Open Life Sciences, 2022 Unexplained recurrent spontaneous abortion (URSA) is a major concern in reproductive medicine. Neutrophil cytosolic factor 1 (NCF1) polymorphisms leading to low production of reactive oxygen species (ROS) are strongly associated with autoimmune diseases.
Du Mengxuan +9 more
doaj +2 more sources
Hypoxia-driven circ-TBC1D1/miR-520h/EPHB4 impairs trophoblast function in unexplained recurrent spontaneous abortion [PDF]
Scientific ReportsHypoxia during early pregnancy critically regulates trophoblast function, and its dysregulation has been implicated in unexplained recurrent spontaneous abortion (URSA).
Rong Hua +10 more
doaj +2 more sources
KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion [PDF]
Journal of Translational MedicineBackground Recurrent spontaneous abortion (RSA) is defined as two or more consecutive spontaneous abortions before 20 weeks with the same spouse [1].
Yiling Tan +7 more
doaj +2 more sources
Significant correlation of angiotensin converting enzyme and glycoprotein IIIa genes polymorphisms with unexplained recurrent pregnancy loss in north of Iran [PDF]
Iranian Journal of Reproductive Medicine, 2016 Background: Spontaneous abortion is considered as the most complex problem during pregnancy. Thrombophilia is resumed as a cause of recurrent pregnancy loss (RPL). Glycoprotein IIIa (GPIIIa) gene is involved in thrombosis and abortion.
Shokoufeh Fazelnia +2 more
doaj +3 more sources
Low-dose aspirin protects unexplained recurrent spontaneous abortion via downregulation of HMGB1 inflammation activation [PDF]
Frontiers in Endocrinology, 2022 BackgroundHigh mobility group box protein 1 (HMGB1) is considered as a kind of sterile inflammatory mediators, which is an overexpression in patients with unexplained recurrent spontaneous abortion (URSA).
Xiaofeng Xu +39 more
doaj +2 more sources
AMPK-mTOR pathway modulates glycolysis reprogramming in unexplained recurrent spontaneous abortion [PDF]
BMC Pregnancy and ChildbirthBackground Recurrent spontaneous abortion (RSA), whose underlying cause has yet to be fully elucidated, is often classified as unexplained recurrent spontaneous abortion (URSA).
Yihong Chen +5 more
doaj +2 more sources
circRNA-DURSA regulates trophoblast apoptosis via miR-760-HIST1H2BE axis in unexplained recurrent spontaneous abortion [PDF]
Molecular Therapy: Nucleic Acids, 2021 Unexplained recurrent spontaneous abortion (URSA) is one of the most intractable clinical challenges in reproduction. As a specific type of endogenous non-coding RNA, circular RNAs (circRNAs) have great pre-clinical diagnostic and therapeutic values in ...
Minyue Tang +10 more
doaj +2 more sources