Defining the role of FMR1 gene in unexplained recurrent spontaneous abortion. [PDF]
Recurrent spontaneous abortion is a multifactorial disorder and till date, various factors have been attributed in its pathogenesis. Still, approximately 50% of RSA cases remain unexplained. Premutation (PM) expanded allele of fragile-X mental retardation 1 (FMR1) gene is known to contribute to ovarian dysfunction in 20% of the cases.
Dean DD, Agarwal S, Muthuswamy S.
europepmc +4 more sources
Deciphering N7-methylguanosine-driven immune dysregulation in unexplained recurrent spontaneous abortion based on transcriptome data and experimental validation [PDF]
Background Unexplained recurrent spontaneous abortion (URSA) poses significant clinical challenges, with immune dysregulation at the maternal–fetal interface implicated in 80% of cases.
Qing Guo +3 more
doaj +2 more sources
Seroprevalence of CMV and Rubella in Women with Recurrent Spontaneous Abortion in Comparison with Normal Delivery [PDF]
Background & Objectives: Recurrent spontaneous abortion occurs by different etiological causes including viral infections. Cytomegalovirus and rubella infections can cause or promote the recurrent fetal loss. Cytomegalovirus is one of the important viral
Padideh Ebadi +3 more
doaj +2 more sources
Daphnetin alleviates unexplained recurrent spontaneous abortion by regulating the NR4A1/BACH2 axis in mice [PDF]
Background Daphnetin has demonstrated various pharmacological activities. The current study evaluated the potential of daphnetin in alleviating unexplained recurrent spontaneous abortion (URSA) and explored underlying mechanisms.
Zhiqin Zhang +6 more
doaj +2 more sources
Evaluation of the role of CD56 cells in unexplained recurrent spontaneous abortion [PDF]
Objective: To determine whether peripheral natural killer (NK) cells play a role in recurrent miscarriage by evaluating the percentage of these cells using flow cytometry and comparing it with the percentages in normal multiparous women and women who experienced miscarriage only once.
Ahmed Kasem Mohamed Zain Eldin +2 more
openaire +2 more sources
To investigate the M1/M2 polarity of macrophages in the endometrium among different menstrual cycles, normal and abnormal pregnancies, and unexplained recurrent spontaneous abortions (RSAs).Endometrial tissue was obtained from 43 patients undergoing hysterectomy, either in the follicular phase (Group 1, n = 23) or in the luteal phase (Group 2, n = 20).
Yih-leong Chang, Ming-Yih Wu, Chen-Tu Wu
exaly +4 more sources
Clinical predictive value of pre-pregnancy tests for unexplained recurrent spontaneous abortion: a retrospective study [PDF]
IntroductionEarly prediction and intervention are crucial for the prognosis of unexplained recurrent spontaneous abortion (uRSA). The main purpose of this study is to establish a risk prediction model for uRSA based on routine pre-pregnancy tests, in ...
Jinming Wang +18 more
doaj +2 more sources
The alteration and potential relationship of vaginal microbiota and chemokines for unexplained recurrent spontaneous abortion. [PDF]
Abstract The diagnosis and treatment of unexplained recurrent spontaneous abortion (URSA) is an important and hot topic in the field of obstetrics and gynecology. During our clinical investigation (observation), we have found that URSA patients usually experience recurrent vaginitis or vaginal dysbacteriosis during periods of ...
Fan T +6 more
europepmc +3 more sources
Emerging per- and polyfluoroalkyl substances (PFAS) alternatives are increasingly used in daily life. Although legacy PFAS have been associated with miscarriage in previous studies, it remains unknown whether exposure to emerging and legacy PFAS has any ...
Min Nian +6 more
doaj +3 more sources
Study on the immunomodulatory mechanism of vitamin D in patients with unexplained recurrent spontaneous abortion. [PDF]
To investigate the mechanism of vitamin D level on the regulation of peripheral blood lymphocyte subsets and serum Th1/Th2 cytokines in patients with unexplained recurrent spontaneous abortion (URSA).Eighty female patients with URSA attending Sichuan Jinxin Xinan Women's and Children's Hospital from January 2020 to May 2021 were selected as the study ...
Yang P, Lu F.
europepmc +4 more sources

