Gut microbiota-derived metabolites associate with circulating immune cell subsets in unexplained recurrent spontaneous abortion [PDF]
HeliyonCurrently, the precise causes of over 40 % of recurrent spontaneous abortion (RSA) cases cannot be identified, leading to the term “unexplained RSA” (URSA).
Zhi Li +6 more
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Role of oxidant-antioxidant balance on incidence of unexplained recurrent spontaneous abortion at first trimester of pregnancy [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2017 The present study was aimed to investigate one of the causes for unexplained recurrent spontaneous abortion at first trimester of pregnancy by determining the levels of Oxidative stress (Malondialdehyde) and determine the levels of Antioxidant defense ...
Hiba M. Saleem, thaer A. SALIH
doaj +2 more sources
Clinical and Experimental Obstetrics & Gynecology, 2023 Background: In this study, we sought to detect the expression of complement C3 and C4 in serum and maternal-fetal interface in patients with unexplained recurrent spontaneous abortion, and analyze their correlation, in order to explore the clinical ...
Zhengxin Zhou +6 more
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Hypoxia-driven circ-TBC1D1/miR-520h/EPHB4 impairs trophoblast function in unexplained recurrent spontaneous abortion [PDF]
Scientific ReportsHypoxia during early pregnancy critically regulates trophoblast function, and its dysregulation has been implicated in unexplained recurrent spontaneous abortion (URSA).
Rong Hua +10 more
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circRNA-DURSA regulates trophoblast apoptosis via miR-760-HIST1H2BE axis in unexplained recurrent spontaneous abortion [PDF]
Molecular Therapy: Nucleic Acids, 2021 Unexplained recurrent spontaneous abortion (URSA) is one of the most intractable clinical challenges in reproduction. As a specific type of endogenous non-coding RNA, circular RNAs (circRNAs) have great pre-clinical diagnostic and therapeutic values in ...
Minyue Tang +10 more
doaj +2 more sources
Research hotspots and trends in unexplained recurrent spontaneous abortion (URSA) from 2014 to 2024: a bibliometric analysis [PDF]
Frontiers in MedicineIntroductionRecurrent spontaneous abortion (RSA) represents a significant challenge in obstetrics and reproductive medicine. Causative factors in 40%–50% of RSA couples remain unknown, a condition termed unexplained recurrent spontaneous abortion (URSA).
Yishi Jiang +3 more
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Low-dose aspirin protects unexplained recurrent spontaneous abortion via downregulation of HMGB1 inflammation activation [PDF]
Frontiers in Endocrinology, 2022 BackgroundHigh mobility group box protein 1 (HMGB1) is considered as a kind of sterile inflammatory mediators, which is an overexpression in patients with unexplained recurrent spontaneous abortion (URSA).
Xiaofeng Xu +39 more
doaj +2 more sources
Potential role of circulating microRNAs as a biomarker for unexplained recurrent spontaneous abortion [PDF]
Fertility and Sterility, 2016 To compare circulating microRNA (miRNA) profiles between unexplained recurrent spontaneous abortion (URSA) and normal early pregnancies (NEP) and to evaluate the potential role of circulating miRNA as a biomarker for URSA.Laboratory study using human plasma samples.Special hospital and research institutes.From September 2012 to April 2013, samples of ...
Wei-Bing Qin
exaly +3 more sources
The role and underlying mechanism of FABP4 dysregulation mediated by m6A modification in unexplained recurrent spontaneous abortion [PDF]
Journal of Translational MedicineBackground Unexplained recurrent spontaneous abortion (URSA) poses a significant clinical challenge with an elusive pathogenesis. FABP4 is crucial for lipid homeostasis and placental development, but its specific role and regulatory mechanism in URSA ...
Fangfang Dai +10 more
doaj +2 more sources
LncRNA landscape and associated ceRNA network in placental villus of unexplained recurrent spontaneous abortion [PDF]
Reproductive Biology and Endocrinology, 2023 Background Unexplained recurrent spontaneous abortion (URSA) is one of the most challenging conditions frustrates women of childbearing age profoundly. The gene expression patterns and biological characteristics of placental villus in patients with URSA ...
Minyue Tang +7 more
doaj +2 more sources