Results 21 to 30 of about 7,864 (179)

Temporal changes in cyclinD-CDK4/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion

Molecular Medicine, 2022
Background Deficient endometrial decidualization has been associated with URSA. However, the underlying mechanism is poorly understood. This study aimed to investigate the temporal cytokine changes and the involvement of CyclinD-CDK4/6 and CyclinE-CDK2 ...
Zhuo Chang, Hai-xue Kuang, Xueming Zhou, Hui Zhu, Yang Zhang, Yin Fu, Qiang Fu, Bei Jiang, Wei Wang, Sha Jiang, Li Ren, Lei Ma, Xue Pan, Xiao-ling Feng   +13 more
doaj   +1 more source

Resveratrol alleviates zea-induced decidualization disturbance in human endometrial stromal cells

Ecotoxicology and Environmental Safety, 2021
Decidualization, which endows the endometrium competency to adopt developing embryo and maintain appropriate milieu for following growth, is a pivotal process for human pregnancy.
Sitong Yao, Wei Wei, Rui Cao, Lin Lu, Shijin Liang, Mingjun Xiong, Chen Zhang, Xiaohuan Liang, Yongjiang Ma   +8 more
doaj   +1 more source

A Role for Malignant Brain Tumor Domain-Containing Protein 1 in Human Endometrial Stromal Cell Decidualization

Frontiers in Cell and Developmental Biology, 2020
Up to 30% of women experience early miscarriage due to impaired decidualization. For implantation to occur, the uterine endometrial stromal fibroblast-like cells must differentiate into decidual cells, but the genes required for decidualization have not ...
Sangappa B. Chadchan, Sangappa B. Chadchan, Vineet K. Maurya, Vineet K. Maurya, Gwendalyn L. Krekeler, Gwendalyn L. Krekeler, Emily S. Jungheim, Emily S. Jungheim, Ramakrishna Kommagani, Ramakrishna Kommagani   +9 more
doaj   +1 more source

TGFβ superfamily signaling and uterine decidualization

Reproductive Biology and Endocrinology, 2017
Decidualization is an intricate biological process where extensive morphological, functional, and genetic changes take place in endometrial stromal cells to support the development of an implanting blastocyst.
Nan Ni, Qinglei Li
doaj   +1 more source

ATF3 deficiency impairs the proliferative–secretory phase transition and decidualization in RIF patients

Cell Death and Disease, 2021
Decidualization is a complex process involving cellular proliferation and differentiation of the endometrial stroma and is required to establish and support pregnancy.
Zhilong Wang, Yang Liu, Jingyu Liu, Na Kong, Yue Jiang, Ruiwei Jiang, Xin Zhen, Jidong Zhou, Chaojun Li, Haixiang Sun, Guijun Yan   +10 more
doaj   +1 more source

Regulation of the PI3K/Akt pathway during decidualization of endometrial stromal cells. [PDF]

PLoS ONE, 2017
Infertility is constantly increasing in Canada, where 16% of Canadian couples are experiencing difficulty conceiving. It is thought that infertility can emanate from the dysregulated communication between the embryo and the maternal endometrium. In order
François Fabi, Kathy Grenier, Sophie Parent, Pascal Adam, Laurence Tardif, Valérie Leblanc, Eric Asselin   +6 more
doaj   +1 more source

Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis

Journal of Biomedical Science, 2022
Background Sleep disturbance can cause adverse pregnancy outcomes by changing circadian gene expression. The potential mechanisms remain unclear.
Liyuan Cui, Feng Xu, Chunfang Xu, Yan Ding, Songcun Wang, Meirong Du   +5 more
doaj   +1 more source

SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization

eLife, 2022
The establishment of pregnancy in human necessitates appropriate decidualization of stromal cells, which involves steroids regulated periodic transformation of endometrial stromal cells during the menstrual cycle.
Pinxiu Huang, Wenbo Deng, Haili Bao, Zhong Lin, Mengying Liu, Jinxiang Wu, Xiaobo Zhou, Manting Qiao, Yihua Yang, Han Cai, Faiza Rao, Jingsi Chen, Dunjin Chen, Jinhua Lu, Haibin Wang, Aiping Qin, Shuangbo Kong   +16 more
doaj   +1 more source

Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice

Genes and Diseases, 2021
Embryo implantation and decidualization are crucial for successful pregnancy, which include multiple genes and signaling pathways, while the precise mechanism regarding embryo implantation and decidualization has yet to be explored.
Wenhao Chen, Qian Zhang, Haibin Wang, Dongmei Tan, Yi Tan   +4 more
doaj   +1 more source

Nuclear actin assembly is an integral part of decidualization in human endometrial stromal cells

Communications Biology
Decidualization of the human endometrium is critical for establishing pregnancy and is entailed by differentiation of endometrial stromal cells (ESCs) into decidual cells.
Isao Tamura, Kei Miyamoto, Chiharu Hatanaka, Amon Shiroshita, Taishi Fujimura, Yuichiro Shirafuta, Yumiko Mihara, Ryo Maekawa, Toshiaki Taketani, Shun Sato, Kazuya Matsumoto, Hiroshi Tamura, Norihiro Sugino   +12 more
doaj   +1 more source