Results 161 to 170 of about 111,508 (346)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

RNAseq analysis reveals dynamic metaboloepigenetic profiles of human, mouse and bovine pre-implantation embryos [PDF]

, 2021
Marcella Pecora Milazzotto, Michael Noonan, Marcia de Almeida Monteiro Melo Ferraz   +2 more
openalex   +1 more source

TGFβ1 Activates Lnc‐APUE to Promote Tumor Metastasis via the Alu Element‐Driven STAU1‐Mediated Decay of CDH1 mRNA

Advanced Science, EarlyView.
We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li, Jia‐Hui Huang, Jin‐E Yang, Yi‐Hang Li, Juan‐Zhen Hong, Ting‐Ting Wang, Ying‐Lei Chi, Meng‐Zhi Wu, Wei Wang, Ying Zhu, Shi‐Mei Zhuang   +10 more
wiley   +1 more source

Correction: Different responses of luminal and glandular epithelium during mouse embryo implantation. [PDF]

Front Vet Sci
Cui W, Guan X, Liu P, Xu QX, Xie J, Jiao Y, Jin L, Wang PC, Yang Z.   +8 more
europepmc   +1 more source

The Effect of Different Concentrations of GM-CSF on the Development of Pre-Implantation Embryos in Mice (Pilot Study) [PDF]

, 2004
Behnaz Sheikholslami, Mojdeh Salehnia, Mojtaba Rezazadeh   +2 more
openalex  

Angiogenic factors in relation to embryo implantation

, 2014
Azadeh Bagheri, Yousef Rezaei Chianeh, Pratap Kumar, Pragna Rao   +3 more
openalex   +2 more sources

Interleukin-10 levels in single embryo conditioned media samples help predict implantation [PDF]

, 2003
Matthew G. Retzloff, Catherine M.H. Combelles, Frederick P. Bowman, Catherine Racowsky, Danny J. Schust   +4 more
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Efficacy of glucocorticoids treatment in recurrent embryo implantation failure. [PDF]

Cell Death Discov
Cai QY, Tang WZ, Li ZM, Li JZ, Zhi XQ, Yang QH, Sheng J, Liu TH.   +7 more
europepmc   +1 more source