Results 141 to 150 of about 433,738 (242)

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

open access: yesAdvanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu   +12 more
wiley   +1 more source

Cell-cycle machinery is critical in regulating uterine steroid hormone for embryo implantation and development

open access: yesThe Journal of Clinical Investigation
Proper embryo implantation is necessary for a successful pregnancy. In this issue of the JCI, Aljubran et al. identified the cell cycle regulatory protein cyclin A2 (CCNA2) as a factor in supporting embryo implantation and embryo development. Endometrial
Francesco J. DeMayo
doaj   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

open access: yesAdvanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang   +9 more
wiley   +1 more source

Paternal age and sperm DNA fragmentation independently affect embryonic ploidy but not euploid embryo implantation potential. [PDF]

open access: yesFront Endocrinol (Lausanne)
Li Z   +10 more
europepmc   +1 more source

Porphyrin‐Based Porous Materials for Antibacterial Applications

open access: yesAdvanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang   +4 more
wiley   +1 more source

FTO Controls Endometrial Receptivity and Embryo Implantation through Regulating m<sup>6</sup>A and H3K27me3. [PDF]

open access: yesCommun Biol
Zhang M   +9 more
europepmc   +1 more source

Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits

open access: yesAdvanced Science, EarlyView.
This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou   +3 more
wiley   +1 more source

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