Results 131 to 140 of about 62,103 (297)

Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems - Step-by-Step Maternal Recognition of the Developing Embryo

, 2016
In humans, HCG secreted from the implanting embryo stimulates progesterone production of the corpus luteum to maintain embryo implantation. Along with this endocrine system, current evidence suggests that the maternal immune system positively contributes
Kanzaki, Hideharu, 30767249, 24288, 24289, Saito, Shigeru, Mori, Takahide, Araki, Yoshihiko, Daikoku, Takiko, Imakawa, Kazuhiko, 大黒, 多希子, Shigeta, Minoru, 24284, 24285, 24286, 24287, 30252456, Fujiwara, Hiroshi, 藤原, 浩, 31, 24290   +19 more
core   +2 more sources

Long‐Term Follow Up of Two Patients With Variants in the Cluster 1031‐1159 of TRRAP Gene: Expanding the Phenotype of Developmental Delay With or Without Dysmorphic Facies and Autism

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The transformation/transcription domain‐associated protein (TRRAP) gene encodes a large multidomain protein, a member of the phosphatidylinositol 3‐kinase‐related kinase (PIKK) family. TRRAP is a component of the histone acetyltransferase (HAT) complex, and it plays an important role in gene transcription, DNA repair, and cell‐cycle regulation.
Roseli Maria Zechi‐Ceide, Vinicius Contrucci Dantas Segarra, Siulan Vendramini‐Pittoli, Henrique Regonaschi Serigatto, Luiza Virmond, Heloisa Marcelina da Cunha Palhares, Fernanda Jehee, Ana Cristina Victorino Krepischi, Carla Rosenberg, Carlos Henrique Paiva Grangeiro, Nancy Mizue Kokitsu‐Nakata   +10 more
wiley   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

MicroRNA biomarkers in human embryo-endometrial implantation

Embryo-endometrial implantation is a crucial process in establishing pregnancy, with microRNAs (miRNAs) playing a significant role in regulating gene expression related to this process.
Khalifa, Dalia Elmusharaf, Hamad, Mosab Nouraldein Mohammed, Bagabas, Marwah Salem, Elbadri , Fania Abdallah   +3 more
core   +2 more sources

Association of Hyaluronic Acid-Enriched Transfer Medium (HETM) with Clinical Pregnancy Outcome in Women Undergoing Frozen-Thawed Embryo Transfer (FET)

Journal of Pharmacy and Bioallied Sciences
Background: Recurrent implantation failure is one of the most important problems in the assisted reproduction technologies, such as women who want frozen-thawed embryo transfers.
Achal Warhade, Akash More, Namrata Choudhary, Ganesh Kalaskar, Prajwal Warhade   +4 more
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Implantation of the Human Embryo

, 2012
Implantation is the final frontier to embryogenesis and successful pregnancy. Over the past three decades, there have been tremendous advances in the understanding of human embryo development. Since the advent of In Vitro Fertilization, the embryo has been readily available to study outside the body.
openaire   +2 more sources

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Inhibition of ERK and GSK3 signalling pathways promotes development and expression of pluripotent markers in bovine blastocysts

, 2012
Embryo-derived pluripotent stem cells (ePSCs) naturally derive from different founder tissues, namely the early and late epiblast, that vary in their cellular characteristics. Recent evidence in mice suggests these sources of starting material correspond
Harris, Daina
core  

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source