Results 111 to 120 of about 7,106,650 (202)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Does the transfer of a poor quality embryo together with a good quality embryo affect the In Vitro Fertilization (IVF) outcome?

, 2017
Background IVF cycles which result in only one good quality embryo, and a second poor quality embryo present a dilemma when the decision involves transferring two embryos.
Wintner, Eliana, Shulman, Adrian, Wintner, Oren, Hershko-Klement, Anat, Gonen, Ofer, Ghetler, Yehudith, Wiser, Amir, Tzadikevitch, Keren   +7 more
core  

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Does the Transfer of a Poor-Quality Embryo alongside a Good-Quality Embryo at the Cleavage or Blastocyst Stage Affect Pregnancy Rates? A Retrospective Cohort Study

Clinical and Experimental Obstetrics & Gynecology
Background: Embryo quality is a critical determinant of success in assisted reproductive technology (ART). A strong and positive correlation between embryo quality and clinical pregnancy rate (CPR) has been reported.
Bülent Emre Bilgiç, Gülşah İlhan, İlhan Şanverdi, Çiğdem Yayla Abide, Nazan Usal Tarhan, Hüseyin Tayfun Kutlu   +5 more
doaj   +1 more source

Method for Determining Embryo Viability and Quality

, 2014
Processo: WO2014089647Número de publicação: WO2014089647 (A1)Número de aplicação: WO2013BR00506The invention described is a method for determining embryo viability and quality that makes a quick evaluation possible, with minimal interference in the ...
Matos, Felipe Delestro, Rocha, José Celso [UNESP], Nogueira, Marcelo Fabio Gouveia [UNESP]   +2 more
core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

The association of embryo transfer quality with clinical outcomes of ICSI treatment of oligozoospermia.

, 2016
The association of embryo transfer quality with clinical outcomes of ICSI treatment of oligozoospermia.
Xianqin Qu (733678), Huijuan Shi (398246), Yongning Lu (108048), Luiwen Zhao (3134583), Xingliang Jin (733679), Minzhi Gao (3134586), Jufeng Zheng (158910), Peng Wang (34436)   +7 more
core   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

La fragmentación de ADN espermático, influencia sobre las técnicas de reproducción asistida y la calidad embrionaria The influence of sperm DNA fragmentation on assisted reproduction techniques and embryo quality

Revista Colombiana de Obstetricia y Ginecología, 2010
Objetivo: presentar una revisión de la literatura sobre la fragmentación del ADN espermático, su impacto en las técnicas de reproducción asistida y la calidad embrionaria. Metodología: se utilizó la base de datos MEDLINE/PubMed.
Alfredo Góngora-Rodríguez, Diana Fontanilla-Ramírez   +1 more
doaj  

Deep learning applications for human embryo assessment using time-lapse imaging: scoping review

Frontiers in Reproductive Health
BackgroundThe integration of deep learning (DL) and time-lapse imaging technologies offers new possibilities for improving embryo assessment and selection in clinical in vitro Fertilization (IVF).ObjectivesThis scoping review aims to explore the range of
Rawan AlSaad, Leen Abusarhan, Nour Odeh, Alaa Abd-alrazaq, Fadi Choucair, Rachida Zegour, Arfan Ahmed, Sarah Aziz, Javaid Sheikh   +8 more
doaj   +1 more source