Results 81 to 90 of about 117,827 (298)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Zdravniški Vestnik, 2011 Background: In unstimulated in vitro fertilization cycles we analysed which criteria for the assessment of day-3-embryo quality were the most important predictive factors of successful implantation.
Mojca Čižek Sajko +1 more
doaj
Diagnostics, 2020 In vitro fertilization can be an effective tool to manage the endometriosis-associated infertility, which accounts for 10% of the strategy indications. Nevertheless, a negative effect of endometriosis on IVF outcomes has been suggested.
Ana M. Sanchez +9 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Clinical aspects of embryo implantation: from the perspective of tissue perfusion.
, 2006 Hypothesis: Pelvic perfusion is the pivotal factor for the outcome of in vitro fertilisation (IVF) treatment once clinical and embryological variables are controlled for their effect.;Demonstration of Hypothesis: In a series of three studies, the ...
Ozturk, O., Ozturk, Ozkan
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: A Review
Antioxidants, 2020 Mitochondria produce adenosine triphosphate (ATP) while also generating high amounts of reactive oxygen species (ROS) derived from oxygen metabolism. ROS are small but highly reactive molecules that can be detrimental if unregulated.
Cristina Rodríguez-Varela +1 more
doaj +1 more source
HLA-G MOLECULES: FROM EMBRYO IMPLANTATION TO OOCYTE MATURATION
, 2009 Background Assisted reproduction technique (ART) pregnancy rates have not changed in recent years and an increased risk of twins, triplets or higher order pregnancies leads to a perinatal mortality and morbidity.
Rizzo, Roberta
core
A novel isolator-based system promotes viability of human embryos during laboratory processing
, 2012 In vitro fertilisation (IVF) and related technologies are arguably the most challenging of all cell culture applications. The starting material is a single cell from which one aims to produce an embryo capable of establishing a pregnancy eventually ...
Fenwick, Jeanette +44 more
core +1 more source