Results 141 to 150 of about 270,879 (312)
MYC: The Guardian of Its Own Chaos
BioEssays, EarlyView.MYC is an oncogene that drives tumorigenesis through enhanced transcription and replication. Paradoxically, MYC induces transcriptional and replicative stress and acts as a resilience factor against these stressors. We discuss how MYC balances these stressors to promote tumor growth while evading immune detection and propose strategies to target MYC ...
Abdallah Gaballa +2 more
wiley +1 more source
Specification of cell fate in the sea urchin embryo: summary and some proposed mechanisms [PDF]
, 1998 An early set of blastomere specifications occurs during cleavage in the sea urchin embryo, the result of both conditional and autonomous processes, as proposed in the model for this embryo set forth in 1989.
Cameron, R. Andrew +2 more
core
A simple mechanochemical model for calcium signalling in embryonic epithelial cells [PDF]
arXiv, 2019 Calcium (Ca2+) signalling is one of the most important mechanisms of information propagation in the body. In embryogenesis the interplay between Ca2+ signalling and mechanical forces is critical to the healthy development of an embryo but poorly understood.
arxiv
Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly
Cytoskeleton, EarlyView.ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley +1 more source
Developmental and genomic architecture of plant embryogenesis: from model plant to crops
Plant Communications, 2021 Embryonic development represents an important reproductive phase of sexually reproducing plant species. The fusion of egg and sperm produces the plant zygote, a totipotent cell that, through cell division and cell identity specification in early ...
Alma Armenta-Medina +6 more
doaj
Multicell-Fold: geometric learning in folding multicellular life [PDF]
arXivDuring developmental processes such as embryogenesis, how a group of cells fold into specific structures, is a central question in biology that defines how living organisms form. Establishing tissue-level morphology critically relies on how every single cell decides to position itself relative to its neighboring cells.
arxiv
Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions
Cancer Nexus, EarlyView.ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Background Environmental influence is critical for embryogenesis but is significantly under‐appreciated under lab conditions, which are not typically designed to robustly test environmental variability. Here, we report environmental effects on the developmental phenotype of zebrafish lacking the transcription factor Grainyhead‐like 3 (grhl3 ...
Nishanthi Mathiyalagan +5 more
wiley +1 more source
On the Interaction of Extreme-Low-Frequency Radiation with Living Matter's Coherent Spiral States [PDF]
arXiv, 1996 Conventional physics cannot explain bioeffects caused by ELF fields [1]. A (double) resonance interaction of ELF radiation with the highly sub-thermal coherent motion of spiral waves in living matter (LM) is suggested. The (geo)magnetic cyclotron resonance (CR) absorption by the constituent ions can drastically change their non-thermal degrees of ...
arxiv
Developmental Dynamics, EarlyView.Abstract Background The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β‐Catenin is significant to this transition due to its dual role as both a structural component in the cadherin–catenin complex and as a ...
Brian M. Walters +5 more
wiley +1 more source