Results 321 to 330 of about 338,049 (387)

Decoding the Molecular Landscape of Prepubertal Oocyte Maturation: GTPBP4 as a Key Driver of In Vitro Developmental Competence

open access: yesCell Proliferation, EarlyView.
Transcriptional and translational characteristics during goat oocyte maturation and identification of key factors, including GTPBP4, for prepubertal goat oocyte maturation. ABSTRACT The intricate mechanisms driving oocyte maturation remain only partially understood, especially within the domains of domestic animal reproduction and translational ...
Jianpeng Qin   +21 more
wiley   +1 more source

A genomic approach to study developmental regulation during oil palm somatic embryogenesis and epigenetic modifications associated with 2,4-D utilization [PDF]

open access: yes, 2005
Borgel, Alain   +5 more
core  

Deciphering Sequence Determinants of Zygotic Genome Activation Genes: Insights From Machine Learning and the ZGAExplorer Platform

open access: yesCell Proliferation, EarlyView.
We compiled a comprehensive set of ZGA genes from mice, humans, pigs, bovines and goats, demonstrating the cross‐species conservation. An interpretable machine learning model, based on k‐mer core features, accurately predicted ZGA genes, revealing abundant and intricate six‐base sequence‐specific patterns and potential binding TFs.
Jixiang Xing   +7 more
wiley   +1 more source

Mechanotransduction Mediated by PDLIM5: The Critical Role of Serpin E2/Integrin β3‐Cytoskeleton‐Nucleoskeleton Axis in Mechanical Osteogenic Programming

open access: yesCell Proliferation, EarlyView.
Large segmental bone defects can result in non‐union of fractures and present a formidable challenge in clinical management. This study aims to investigate the role of mechanical stimulation in regulating osteogenic differentiation of stem cells via the mechanosensitive protein PDLIM5, thereby promoting bone regeneration and repair.
Yuchao Yang   +13 more
wiley   +1 more source

Chip (Ldb1) is a new cofactor of Zelda forming a functional bridge to CBP during zygotic genome activation

open access: yes
Galouzis CC   +5 more
europepmc   +1 more source

Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF Signalling

open access: yesCell Proliferation, EarlyView.
Paracrine FGF4 from EPI precursor cells promotes lactate synthesis within PrE precursor cells, while the increased lactate in turn stimulates FGF‐ERK signalling via lactate shuttling. The increased lactate in PrE precursor cells directly promotes PrE formation by elevating the level of histone lactylation. ABSTRACT Lactate has been widely recognised as
Xiao Hu   +9 more
wiley   +1 more source

Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA. [PDF]

open access: yesProtein Cell
Zhang X   +8 more
europepmc   +1 more source

Autophagy in PE: Dispute, Role and Potential Target

open access: yesCell Proliferation, EarlyView.
Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu   +12 more
wiley   +1 more source

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