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Mechanosensing in embryogenesis

Current Opinion in Cell Biology, 2021
Mechanical forces generated by living cells at the molecular level propagate to the cellular and organismal level and have profound consequences for embryogenesis. A direct result of force application is movement, as occurs in chromosome separation, cell migration, or tissue folding.
Ronen Zaidel-Bar, Priti Agarwal
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The T genes in embryogenesis

Trends in Genetics, 1994
Since its identification in 1927, the mouse T (Brachyury) locus has been implicated in mesoderm formation and notochord differentiation. Recent work has demonstrated that this gene encodes a putative transcription factor expressed specifically in nascent mesoderm and in the differentiating notochord.
Andreas Kispert, Bernhard G. Herrmann
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Embryogenesis of Chordee

Journal of Urology, 1975
Gross and microscopic examination of 46 consecutive male therapeutic abortion specimens, ranging in size from 60 to 180 mm. crown-rump, demonstrated that 89 per cent of the fetuses had some ventral curvature of the penis. Athough presumably all penises are ventrally curved through the tenth week of gestation, in our study this curvature was most ...
George W. Kaplan, Donald L. Lamm
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Embryogenesis of holoprosencephaly

American Journal of Medical Genetics Part A, 2007
AbstractHoloprosencephaly (HPE) is a malformation of the human brain caused primarily by incomplete division of the prosencephalon into two halves and is often associated with various facial anomalies. Although HPE is rather rare in newborns (1/10,000–15,000 births), it is frequently encountered in therapeutic abortuses (>1/250).
Shigehito Yamada   +3 more
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Diffusion in Embryogenesis

Nature, 1970
A simple order-of-magnitude calculation suggests that diffusion may be the underlying mechanism in establishing morphogenetic gradients in embryonic development.
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In vitro embryogenesis

Science, 2017
Developmental Biology Pluripotent embryonic stem cells (ESCs) can differentiate into any adult cell type; however, aggregates of these cells do not mimic embryonic architecture when grown in culture. To see whether mouse ESCs and their extraembryonic counterparts, trophoblast stem cells (TSCs), can recapitulate normal development, Harrison et al ...
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