Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Achilles And The Tortoise: Some Caveats To Mathematical Modeling In Biology [PDF]
, 2018 Mathematical modeling has recently become a much-lauded enterprise, and many funding agencies seek to prioritize this endeavor. However, there are certain dangers associated with mathematical modeling, and knowledge of these pitfalls should also be part ...
Gilbert, Scott F.
core +3 more sources
A Functional Perspective on the Embryology and Anatomy of the Cerebral Blood Supply
Journal of Stroke, 2015 The anatomy of the arterial system supplying blood to the brain can influence the development of arterial disease such as aneurysms, dolichoectasia and atherosclerosis.
Khaled Menshawi, J. Mohr, J. Gutierrez
semanticscholar +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
The early stages of heart development: insights from chicken embryos [PDF]
, 2016 The heart is the first functioning organ in the developing embryo and the detailed understanding of the molecular and cellular mechanisms involved in its formation provides insights into congenital malformations affecting its function and therefore the ...
Alsan +19 more
core +2 more sources
Artificial intelligence in the embryology laboratory: a review.
Reproductive Biomedicine Online, 2021 I. Dimitriadis +3 more
semanticscholar +1 more source
Rediscovering Jain Medicine: An Aspect of Ancient Indian Medicine through the Embryology of the Taṇḍulaveyāliya [PDF]
UisahakThis study reexamines the position and significance of the Jain medical tradition, long marginalized in the history of Indian medicine, by analyzing the embryological discourse in the Jain text Taṇḍulaveyāliya.
Youngsun YANG
doaj +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Two means two, but must does not mean must:an analysis of recent decisions on the conditions for parental orders in surrogacy [PDF]
, 2018 This article examines the High Court decisions in Re Z (A Child) (Surrogate Father: Parental Order) [2017] 1 FLR 472 and Re X (A Child) (Parental Order: Time Limit) [2015] 1 FLR 349, which concerned two of the conditions for the granting of ‘parental ...
Brown, Alan
core