Results 91 to 100 of about 78,942 (313)

Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids

Nature Communications
Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity.
Thomas A. Kluiver, Yuyan Lu, Stephanie A. Schubert, Lianne J. Kraaier, Femke Ringnalda, Philip Lijnzaad, Jeff DeMartino, Wouter L. Megchelenbrink, Vicky Amo-Addae, Selma Eising, Flavia W. de Faria, Daniel Münter, Marc van de Wetering, Kornelius Kerl, Evelien Duiker, Marius C. van den Heuvel, Vincent E. de Meijer, Ruben H. de Kleine, Jan J. Molenaar, Thanasis Margaritis, Hendrik G. Stunnenberg, Ronald R. de Krijger, József Zsiros, Hans Clevers, Weng Chuan Peng   +24 more
doaj   +1 more source

Retromolar Embryonal Rhabdomyosarcoma: A Case Report

JBN (Jurnal Bedah Nasional), 2017
Background: embryonal rhabdomyosarcoma is common of rhabdomyosarcoma, usually in 5 years old child. Approximately 28% of embryonal rhabdomyosarcomas occur in head and neck area, and 0.04% of cases occur as intra-oral tumors.
Caryl Augustine Johanna, Gede Budhi Setiawan   +1 more
doaj   +1 more source

Intratubular Embryonal Carcinoma

Archives of Pathology & Laboratory Medicine, 2002
Abstract Although intratubular embryonal carcinoma has been described adjacent to invasive embryonal carcinoma, to our knowledge it has not been reported as an isolated finding. We present in this report the histologic and immunohistochemical findings of 2 cases of intratubular embryonal carcinoma.
Dinesh, Rakheja, Mai P, Hoang, Suash, Sharma, Jorge, Albores-Saavedra   +3 more
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells [PDF]

, 2017
EPH (erythropoietin-producing hepatocellular) receptors are clinically relevant targets in several malignancies. This report describes the effects of GLPG1790, a new potent pan-EPH inhibitor, in human embryonal rhabdomyosarcoma (ERMS) cell ...
Beirinckx, Filip, Camero, Simona, Ceccarelli, Simona, DE FELICE, Francesca, Del Fattore, Andrea, Der Aar, Ellen Van, Desiderio, Vincenzo, Dominici, Carlo, Festuccia, Claudio, Gravina, GIOVANNI LUCA, Maggio, Roberto, Marampon, Francesco, Marchese, Cinzia, Mcdowell, Heather P, Megiorni, Francesca, Papaccio, Federica, Pizzuti, Antonio, Pujuguet, Philippe, Saniere, Laurent, Shukla, Rajeev, Tombolini, Vincenzo   +20 more
core   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Primary undifferentiated embryonal sarcoma of the liver mistaken for hydatid disease

World Journal of Surgical Oncology, 2010
Primary undifferentiated embryonal sarcoma of the liver is a rare tumor with a peak incidence between the ages of 6 and 10 years. We report a case of a primary hepatic undifferentiated embryonal sarcoma arising in a 21-year-old male mistaken for hydatid ...
Shamseddine Achraf, Shamseddine Ali, El Majzoub Nadim, Mukherji Deborah, Faraj Walid, Khalife Mohamed   +5 more
doaj   +1 more source

PARsing Embryonic Polarity [PDF]

Cell, 2000
Thus, in spite of widely divergent developmental mechanisms, worms and flies both use a member of the PAR-1/MARK/KIN1 family during an early step in polarity establishment. What does this mean? One possibility is that this is a case of a conserved function being independently co-opted by evolution for use in polarity.
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Multimodality imaging of vaginal rhabdomyosarcoma

Indian Journal of Radiology and Imaging, 2017
Rhabdomyosarcoma (RMS) is a malignant mesenchymal tumor arising from the embryonal muscle cells (rhabdomyoblasts), and is the most common soft tissue sarcoma in children and young adults accounting for 4–6% of all malignancies in this age group.
Richa S Chauhan, Dheeraj K Singh, Bishwarup Guha, Ishan Kumar, Ashish Verma   +4 more
doaj   +1 more source