Results 171 to 180 of about 195,208 (299)

Prolactin Receptor-Associated Protein/17β-Hydroxysteroid Dehydrogenase Type 7 Gene (Hsd17b7) Plays a Crucial Role in Embryonic Development and Fetal Survival [PDF]

, 2008
Aurora Shehu, Jifang Mao, Gil B. Gibori, Julia Halperín, Jamie Le, Y. Sangeeta Devi, Bradley J. Merrill, Hiroaki Kiyokawa, Geula Gibori   +8 more
openalex   +1 more source

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

Parental conditions, modifiable lifestyle factors, and first trimester growth and development: a systematic review. [PDF]

Hum Reprod Update
Graafland N, Rousian M, de Zwart ML, Steegers-Theunissen RPM, Steegers EAP, Posthumus AG.   +5 more
europepmc   +1 more source

Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development

, 2005
Caihong Qiu, Eric T. Hanson, Emmanuel Olivier, Mari Inada, Dan S. Kaufman, Sanjeev Gupta, Eric E. Bouhassira   +6 more
openalex   +1 more source

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells

Advanced Science, EarlyView.
LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang, Yunjun Li, Di Han, Kun Deng, Wei Gao, Minghua Wu   +5 more
wiley   +1 more source

Macrophage is crucial for tongue development by regulating myogenesis and vascularization. [PDF]

BMC Oral Health
Wang Z, Wang M, Liu J, Zhao D, Wang J, Wei F.   +5 more
europepmc   +1 more source

Laminin α1 globular domains 4–5 induce fetal development but are not vital for embryonic basement membrane assembly

, 2005
Susanne Schéele, Marni J. Falk, Ahnders Franzén, Fredrik Ellin, Maria Ferletta, Peter Lonai, Björn Andersson, Rupert Timpl, Erik Forsberg, Peter Ekblom   +9 more
openalex   +1 more source

Human Fetal Liver Stromal Cells Expressing Erythropoietin Promote Hematopoietic Development from Human Embryonic Stem Cells [PDF]

, 2012
Chao Yang, Lei Ji, Wen Yue, Shuangshuang Shi, Ruo-Yong Wang, Yanhua Li, Xiaoyan Xie, Jiafei Xi, Lijuan He, Xue Nan, Xuetao Pei   +10 more
openalex   +1 more source

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

Progress in the study of the effects of selective serotonin reuptake inhibitors (SSRIs) on the reproductive system. [PDF]

Front Pharmacol
Feng Y, Qu X, Hao H.
europepmc   +1 more source