Results 231 to 240 of about 240,921 (300)

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

Effects of administration of a non-specific immunostimulant prior to mating on pregnancy establishment and fetal and placental development in mice. [PDF]

Biochem Biophys Rep
Brown W, Kuzniar M, Retherford S, Mitrisin B, Ingols A, Tena JK, Sucheta SC, Block J.   +7 more
europepmc   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Molecular architecture of mesoderm cells across early to middle stage of human embryo development at single-cell resolution. [PDF]

BMC Mol Cell Biol
Zhang W, Yu H, Zhang Z, Li D, Yang Y, Shi W, Li W, Jiang Y, Hu W, Zeng Z, Liu X, Zheng Z, Ou M, Tang D, Dai Y.   +14 more
europepmc   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

The Structural Order of Crystallin Proteins During Early Human Lens Development. [PDF]

Invest Ophthalmol Vis Sci
Bains KK, Bell J, Young RD, Ma Q, Hayes S, Howard L, Shebanova O, Terrill NJ, Meek KM, Regini JW, Quantock AJ.   +10 more
europepmc   +1 more source

Reviewer #1 (Public review): NR2F2 is required in the embryonic testis for Fetal Leydig Cell development

Aitana Perea-Gomez, Natividad Bellido-Carreras, Magali Dhellemmes, Furong Tang, Coralie Le Gallo, Marie-Christine Chaboissier   +5 more
openalex   +1 more source

Thoraco-Omphalopagus Conjoined Twins Following IVF With Day 5 Embryo Transfer: A Rare Case Report and Multidisciplinary Management Approach. [PDF]

Clin Case Rep
Piekos P, Ravelo N, Ruano R, Attia G.
europepmc   +1 more source

eLife Assessment: NR2F2 is required in the embryonic testis for Fetal Leydig Cell development

Detlef Weigel
openalex   +1 more source