Progesterone signaling in oviductal epithelial cells modulates the immune response to support preimplantation embryonic development. [PDF]
McGlade EA+14 more
europepmc +1 more source
Emerging Therapeutic Strategies for Hearing Loss
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han+9 more
wiley +1 more source
The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis. [PDF]
Aoto M+7 more
europepmc +1 more source
FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang+14 more
wiley +1 more source
From genes to patterns: a framework for modeling the emergence of embryonic development from transcriptional regulation. [PDF]
Garcia-Guillen J, El-Sherif E.
europepmc +1 more source
The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni+16 more
wiley +1 more source
Navigating redox imbalance: the role of oxidative stress in embryonic development and long-term health outcomes. [PDF]
Divvela SSK+5 more
europepmc +1 more source
Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. [PDF]
Karen M. Lyons, Ron W. Pelton, B L Hogan
openalex +1 more source