Results 171 to 180 of about 1,408,830 (315)

Emergence Angle, Marginal Bone Loss, and Radiographic Corticalization Around MIS Implants: A 5-Year Retrospective Study of Single, Splinted, and Bridge Restorations. [PDF]

J Clin Med
Wach T, Kuta K, Michcik A, Hadrowicz P, Szymor P, Pruszyńska P, Trybek G, Sikora M, Kozakiewicz M.   +8 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The Computability-Theoretic Content of Emergence [PDF]

In dealing with emergent phenomena, a common task is to identify useful descriptions of them in terms of the underlying atomic processes, and to extract enough computational content from these descriptions to enable predictions to be made. Generally, the
S. Barry Cooper
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

State-dependent neuronal and network dynamics in the lateral hypothalamus across sevoflurane anesthesia-emergence revealed by microelectrode arrays. [PDF]

Microsyst Nanoeng
Li Q, Jia Q, Song Y, Miao J, Wang Y, Liu Y, Duan Y, Sun B, Luo J, Yang Q, Cai X, Luo Y.   +11 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Virus discovery in sandflies, from field studies to phylogenetic tree building: classic methods versus novel methods, what do we need to address public health impact?

Parasites & Vectors, 2014
L Bichaud, C Alkan, G Piorkowski, E Zhioua, I Bitam, A Izri, V Moin Vaziri, B Alten, Y Ozbel, OE Kasap, X De Lamballerie, RN Charrel   +11 more
doaj   +1 more source

Emergence Angle and Emergence Profile in Implant-Supported Restorations: A Scoping Review. [PDF]

Dent J (Basel)
Prpic V, Gojsovic S, Kosec P, Skec S, Catic A.   +4 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Cultural Differences and Economic Incentives: an Agent-Based Study of Their Impact on the Emergence of Regional Autonomy Movements [PDF]

Explanations of the emergence of regional autonomy movements - political organizations seeking to express sub-state affinities and interests - often highlight cultural differences and economic incentives as important reasons driving regional elites and ...
Dan Miodownik
core