Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Risk management strategies for the 2022 Olympic Winter Games: The Beijing scheme
Journal of Sport and Health Science, 2022 Jie Liu +3 more
doaj +1 more source
Origins of pandemics: Why ecological disruption is central to global health security and the imperative for proactive prevention. [PDF]
One HealthMahmood S, Naden P, Thapa S, Gibbs P.
europepmc +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Emergence, social capital and entrepreneurship: Understanding networks from the inside
, 2011 Communities are a major research context for both social capital and entrepreneurship, and 'networks' is a core concept within both frameworks. There is need for conceptualizing network formation processes, and for qualitative studies of the relational ...
Onyx, J, Baker, E, Edwards, M
core
End-of-Surgery Remimazolam Bolus Reduces Emergence Delirium in Children Undergoing Tonsillectomy and Adenoidectomy: A Randomized, Triple-Blind, Placebo-Controlled Trial. [PDF]
BiomedicinesPrižmić G +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Assessment of cold tolerance in early field emergence in sweet, fiber, and grain sorghums [<i>Sorghum bicolor</i> (L.) Moench]. [PDF]
Front Plant SciPatanè C +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Fire-Disturbed Soil and Intraspecific Competition Modulate Juvenile Performance of Invasive <i>Hakea decurrens</i> subsp. <i>physocarpa</i>. [PDF]
Plants (Basel)Morais MC +4 more
europepmc +1 more source