Results 141 to 150 of about 1,727,958 (299)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Clarifying the Assessment of Emergence Agitation and Postoperative Recovery in Young Children Receiving Ciprofol or Propofol for Dental Surgery [Letter]. [PDF]

Drug Des Devel Ther
Zhao Q.
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Seeds of change: trait shifts over time in wild plant populations revealed using <i>ex situ</i> Seeds of Success collections. [PDF]

AoB Plants
Shriver LC, Barga SC, Leger EA.
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Assessment: An Unresolved Intercurrent Event in a Randomized Trial of Ciprofol versus Propofol [Response to Letter]. [PDF]

Drug Des Devel Ther
Zhang Y, Wu L, Gao Z, Zhang M, Feng C, Zhang H, Zhang H, Liu B.   +7 more
europepmc   +1 more source

Living evidence profile 7.3: Examining what is known about the emergence, transmission, and spectrum of the burden of disease of avian influenza A(H5Nx) subtypes

An overview of the best available research evidence from around the world (i.e., evidence syntheses) and local research evidence (i.e., single studies) and, if applicable, a scan of experiences from other countries and from Canadian provinces and ...
Alam, S, Chen, K, Wu, N, DeMaio, P, Bain, T, Waddell, K, Wilson, MG, Velez, CM, Wang, Q, Bhuiya, AR, Ciurea, P   +10 more
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Implementing contingency management to improve engagement among justice-involved clients referred for substance use disorder services. [PDF]

Front Public Health
Hartzler B, Feltner A, Wig C, Tran J, Nugent M, Verbeck J, Payne K, McIlveen JW.   +7 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source