Results 21 to 30 of about 1,408,830 (315)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Identification of anisotropic material properties considering in-plane isotropy

Nihon Kikai Gakkai ronbunshu
Finite elements analysis (FEA) has been widely used for evaluating the performance of products in practical engineering design processes. In the FEA of industrial equipment, such as large-scale motors and transformers, the accurate identification of ...
So FUKUHARA, Tasuku YUNOKI, Toshiaki HIRATE, Kenzen TAKEUCHI, Masao ARAKAWA   +4 more
doaj   +1 more source

Biosafety and Biosecurity in European Containment Level 3 Laboratories: Focus on French Recent Progress and Essential Requirements

Frontiers in Public Health, 2017
Even if European Union (EU) Member States are obliged to implement EU Directives 2000/54/EC on the protection of workers from risks related to exposure to biological agents at work, national biosafety regulations and practices varied from country to ...
Boris Pastorino, Boris Pastorino, Xavier de Lamballerie, Xavier de Lamballerie, Rémi Charrel, Rémi Charrel   +5 more
doaj   +1 more source

Emergence of mammals by emergency: exaptation [PDF]

Genes to Cells, 2010
With the development of molecular embryology and the coming of the post‐genomic era, the molecular mechanisms of morphological evolution have recently begun to be elucidated. Whole genome sequences of many vertebrate species have been determined, and comparative genomics has suggested that one source of biodiversity is conserved non‐coding elements ...
Okada N, Sasaki T, Shimogori T, Nishihara H.   +3 more
openaire   +2 more sources

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Hardware-Efficient CPG Model Based on a Ring of Unidirectionally Coupled Oscillators With Perturbation of State Transition Timing

IEEE Access
A ring of unidirectionally coupled phase oscillators is simple and easy to implement but not suitable for application to central pattern generators (CPGs) owing to the presence of coexisting stable equilibria corresponding to a gait and useless pattern ...
Takumi Yoshioka, Kentaro Takeda
doaj   +1 more source

Metabolic Effects of a Succinic Acid

Общая реаниматология, 2014
The paper discusses promises for clinical use of substrate antihypoxants.Objective: to investigate the efficacy of succinate containing  substrate  antihypoxants  on  systemic  oxygen  consumption,  blood  buffer  capacity,  and  changes  in  the  mixed ...
B. N. Shakh, V. N. Lapshin, A. G. Kyrnyshev, D. B. Smirnov, N. R. Kravchenko-Berezhnaya   +4 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Less is Different: Emergence and Reduction Reconciled [PDF]

, 2010
This is a companion to another paper. Together they rebut two widespread philosophical doctrines about emergence. The first, and main, doctrine is that emergence is incompatible with reduction.
Butterfield, Jeremy, J. Butterfield
core   +1 more source

Tularemia: emergence/re-emergence [PDF]

Veterinary Research, 2005
Francisella tularensis is a gram-negative coccobacillus and the etiologic agent of the zoonotic disease tularemia. First described in 1911 in Tulare County, California, it has since been reported throughout the Northern Hemisphere, with natural infections reported among an unusually wide range of vertebrates and invertebrates.
Petersen, Jeannine M., Schriefer, Martin E.   +1 more
openaire   +3 more sources