Results 61 to 70 of about 793,756 (249)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
International Journal of COPDShengwei Wang, Weiwei Tang, Haixia Yang Department of Emergence Medicine, Nanjing Brain Hospital, Nanjing, Jiangsu, 210029, People’s Republic of ChinaCorrespondence: Haixia Yang, Email yanghx8801@163.comPurpose: Chronic obstructive pulmonary disease ...
Wang S, Tang W, Yang H
doaj
Journal of Advanced Mechanical Design, Systems, and ManufacturingMotorcycle assistance systems have been an increasing focus of research in recent years to promote safer riding practices and mitigate motorcycle-related accidents.
Kifle Hailu GEBRETSADIK, Keisuke SUZUKI
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Prognostic value of systemic immune-inflammation index in the diagnosis of preeclampsia
HeliyonBackground: Preeclampsia is a serious complication of pregnancy with negative consequences for the mother and fetus. It was aimed to investigate whether the systemic immune inflammation index is a parameter that will facilitate the diagnosis of ...
Mucahit Kapci +5 more
doaj +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Development Studies ResearchGrowing disparities in asset ownership and capital accumulation have raised concerns about the role of wealth inequality in shaping long-term development, particularly in low-income countries. Although the inequality–growth nexus has been widely studied,
Bocar Sidi Konaté, Said Hanchane
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Tick exposure biomarkers: A One Health approach to new tick surveillance tools
Current Research in Parasitology and Vector-Borne DiseasesThe spread of tick-borne disease (TBD) is escalating globally, driven by climate change and socio-economic shifts, underlining the urgency to improve surveillance, diagnostics, and control strategies.
Alexis Dziedziech +4 more
doaj +1 more source