Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian +12 more
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Analysis of influencing factors and clinical application of a predictive model for emergence agitation from general anesthesia after abdominal surgery. [PDF]
Wan Y, Ye H, Liu K.
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The ABCABC stacking sequence in 2D ZnIn2S4 nanosheets creates intrinsic non‐centrosymmetry, enabling robust piezocatalysis under weak mechanical agitation. The nanosheets achieve a H2O2 yield of 276.7 µmol g−1 h−1 and uranium extraction capacity of 763.2 mg g−1 via a dual mechanism of direct piezoreduction and in situ H2O2 complexation.
Song Li +6 more
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Comparison between butorphanol and nalbuphine for alleviation of catheter-related bladder discomfort and emergence agitation in patients undergoing open spinal surgery: a randomized clinical trial. [PDF]
Wang W +5 more
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Conceptual illustration of a Global Ecosystem Methane Observing System (GEM‐OS) integrating satellites, aircraft, atmospheric networks, and ecosystem measurements to quantify methane emissions from anthropogenic and natural sources. The multi‐scale observing framework improves source attribution, reduces uncertainty in regional methane budgets, and ...
P. Ciais +32 more
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Nalbuphine in Pediatric Emergence Agitation Following Cochlear Implantation: A Randomized Trial. [PDF]
Li Y +5 more
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Complex microarchitectures emerge from simple flow‐driven transformations as static mixers iteratively reorient and split material domains. Coupled with diverse deposition strategies, chaotic printing provides an accessible platform for fabricating architected materials that support biologically and chemically relevant processes. ABSTRACT Nature builds
Edna Johana Bolívar‐Monsalve +7 more
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"The effect of intramuscular dexmedetomidine versus oral gabapentin premedication on the emergence agitation after rhinoplasty". A prospective, randomized, double-blind controlled trial. [PDF]
Abdelaziz TSA +3 more
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In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong +13 more
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Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study. [PDF]
Huang Q +6 more
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