Results 91 to 100 of about 3,015,220 (299)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An Evolving Hypernetwork Model to Quantify Progress Potential of Emerging Research Topic
MATEC Web of Conferences, 2018 There is considerable and growing interest in the emergence of research topics. However, current methods to detect the emergence are still problematic mainly due to information loss and aging effect.
Liu Jia +4 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
The Nature of the Transformation in Transformational Emergence
, 2018 Discussion about the nature of the transformation in the case of transformational ...
Guay, Alexandre, Diachronic Emergence
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Pattern-driven reuse in architecture-centric evolution for service software [PDF]
, 2012 Service-based architectures implement business processes as technical software services to develop enterprise software. As a consequence of frequent business and technical change cycles, the architect requires a reusecentered approach to systematically ...
Pooyan Jamshidi (5276344) +5 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Emerging consecutive pattern avoidance
CoRRIn this note we study the {\em asymptotic popularity}, that is, the limit probability to find a given consecutive pattern at a random position in a random permutation in the eighteen classes of permutations avoiding at least two length 3 consecutive patterns.
Hassler, Nathanaël, Kirgizov, Sergey
openaire +4 more sources
Texas Pattern Jury Charges [PDF]
, 2018 Guide listing pattern jury charges to assist the bench and bar in preparing the court's charge in the state of Texas, including definitions, instructions, and questions needed to submit jury charges. Indexes to statutes and rules cited, cases cited, and
State Bar of Texas. Committee on Pattern Jury Charges.
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source