Results 101 to 110 of about 3,015,220 (299)
Emergence of the North Pacific heat storage pattern delayed by decadal wind-driven redistribution
Nature CommunicationsStorage of anthropogenic heat in the oceans is spatially inhomogeneous, impacting regional climates and human societies. Climate models project enhanced heat storage in the mid-latitude North Pacific (MNP) and much weaker storage in the tropical Pacific.
Jing Duan +4 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Question mark shaped earrings from Danube Bulgaria(the XIII–XIV cc.): origin and area of spread
Поволжская археология, 2014 A special type of jewelry, earrings shaped as question mark from Bulgaria, is considered. Their spreading area and possible sources of their emergence in the culture of 13-14th-century Danube Bulgaria are made clear.
Vladimirov Georgi V.
doaj
, 1995 Emergence is the process of making properties which were not explicitly represented in a computational system explicit. This paper presents two approaches to graphical emergence suitable or implementation in a CAAD system. It presents processes for shape
J. Damski +5 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 1988 Very Easy Vogue Career Pattern #7382 to make a straight dress with shoulder pads, front overlay, back zipper, and long set-in sleeves, including illustrations of the finished pieces and information about sizing and construction on the ...
Vogue Pattern
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
ONTOLOGY, MATTER AND EMERGENCE [PDF]
, 2007 “Ontological emergence” of inherent high-level properties with causal powers is witnessed nowhere. A non-substantialist conception of emergence works much better.
Bitbol, Michel, Michel, Bitbol
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