Results 61 to 70 of about 821,456 (332)

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

‘A tale of two paradoxes in response to COVID-19’: Public health system and socio-economic implications of the pandemic in South Africa and Zimbabwe.

Cogent Social Sciences, 2021
Africa’s response to the outbreak of infectious diseases has come under scrutiny over the years and the outbreak of COVID-19 has exacerbated the situation.
Bellita Banda Chitsamatanga, Wayne Malinga   +1 more
doaj   +1 more source

Factors influencing hospital emergency evacuation during fire: A systematic literature review

International Journal of Preventive Medicine, 2021
Background: Although the hospital is known as a safe place for treating patients, due to various reasons, it is prone to several internal hazards, including fire.
Ali Sahebi, Katayoun Jahangiri, Ahmad Alibabaei, Davoud Khorasani-Zavareh   +3 more
doaj   +1 more source

Assessing the Medical Emergency Preparedness of Dental Faculty, Residents, and Practicing Periodontists: An Exploratory Study [PDF]

, 2018
With the increased number of elderly and medically compromised individuals receiving dental care and the presence of systemic comorbidities and associated treatment modalities in this patient population, it is imperative that dentists be prepared to ...
Blanchard, Steven, de Bedout, Tatiana, Eckert, George J., Hamada, Yusuke, John, Vanchit, Kramer, Kyle, Maupome, Gerardo   +6 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

INtelligent toolkit for reconnaissance, assessments and prehospital support in Perilous InciDents: a realistic experiment in prehospital environment

BMC Health Services Research
Background First responders, when arriving at a disaster, need a rapid analysis of the environment in which they are going to operate, as they have to assess the conditions surrounding potential victims and neutralize any risks that may exist.The EU ...
Ana María Cintora-Sanz, Patricia Blanco-Hermo, Soledad Gómez-De la Oliva, Rozenn Marechal, Olivier Balet, Patricia Gonzalez-Rico   +5 more
doaj   +1 more source

Impediments to and impact of checklists on performance of emergency interventions in primary care: an in situ simulation-based randomized controlled trial

Scandinavian Journal of Primary Health Care, 2021
Objective Medical crises occur rather seldom in the primary care setting, but when they do, initial management impacts on morbidity and mortality. Factors that impede the performance of emergency interventions in primary care have not been studied ...
Eric Dryver, Jeanette Knutsson, Ulf Ekelund, Anders Bergenfelz   +3 more
doaj   +1 more source

Emerging viruses – is there an emerging pattern? [PDF]

The Biochemist, 2017
The Ebola outbreak in West Africa in 2014 and the spread of Zika across the Americas in 2016 have thrust previously obscure viruses into the media spotlight. But is something new really going on? What can we expect in future? Is there anything we can do?
openaire   +2 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source