Results 81 to 90 of about 578,848 (315)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Translating global education standards to local contexts

Forced Migration Review, 2014
Global standards such as the Education in Emergencies Minimum Standards need to be applied locally and this requires a thoughtful and committed contextualisation process.
Carine Allaf, Tzvetomira Laub, Arianna Sloat   +2 more
doaj  

Epidemiological characteristics of elderly population receiving pre-hospital emergency care after road traffic injuries in Punjab, Pakistan

International Journal of Emergency Medicine
Background Every year, 1.3 million lives are lost to road traffic injuries (RTIs). 90% of these deaths disproportionately occur in Lower-Middle Income Countries (LMICs).
Kantesh Kumar, Sheza Hassan, Muhammad Bazil Musharraf, Komal Abdul Rahim, Sijal Akhtar Sheikh, Huba Atiq, Muhammad Waqas Ahmed, Rameez-ur-Rehman Siddiqui, Rizwan Naseer, Shahnaz Akhter, Yasir Shafiq, Junaid Razzak   +11 more
doaj   +1 more source

Protect Iowa Health, 2005 [PDF]

, 2005
The Iowa Department of Public Health works with local, state and federal partners in developing plans and creating systems to increase the state’s ability to respond to bioterrorism, infectious disease outbreaks and other public health ...

core  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The vulnerability of the European agriculture and food system for calamities and geopolitics : a stress test [PDF]

During the 1960s and 1970s, the EU succeeded in becoming largely self-sufficient in food production, thus assuring its food security for the most part.
Burger, C.P.J., Hees, E., Jansen, D.M., Rougoor, C., Weijden, W., van der   +4 more
core   +2 more sources

Ready or Not? Protecting the Public's Health From Diseases, Disasters, and Bioterrorism, 2008 [PDF]

, 2008
Examines ten indicators to assess progress in state readiness to respond to bioterrorism and other public health emergencies. Evaluates the federal government's and hospitals' preparedness.
Jeffrey Levi, Laura M. Segal, Rebecca St. Laurent, Serena Vinter   +3 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Beyond early warning: towards greater granularity in the use of event-based surveillance for public health emergencies

BMC Public Health
Background The international health emergency caused by the emergence of the SARS-CoV-2 virus demonstrated the expanding usefulness of multi-country disease outbreak information gathered through event-based surveillance (EBS) as an extension beyond the ...
C. J. McKnight, A. T. Aboushady, C. R. Lane   +2 more
doaj   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source