Results 31 to 40 of about 26,824 (263)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Dynamic DNA Nano‐Antioxidant Targeting Galectin‐3 Attenuates Liver Fibrosis via Reducing Macrophage Oxidative Stress

Advanced Science
Liver cirrhosis represents a major global health challenge with significant socioeconomic implications. Oxidative stress‐mediated injury plays a pivotal role in driving fibrotic progression, with hepatic macrophages serving as a dominant source of ...
Mengjia Peng, Jianguo Xu, Youjian Hong, Fei Fang, Yan Li, Duo Ci, Bowen Wang   +6 more
doaj   +1 more source

Clinical efficacy and mechanism of mesenchymal stromal cells in treatment of COVID-19

Stem Cell Research & Therapy, 2022
Coronavirus disease 2019 (COVID-19) is a highly infectious epidemic disease that has seriously affected human health worldwide. To date, however, there is still no definitive drug for the treatment of COVID-19.
Kun Lu, Shi-tao Geng, Shikai Tang, Hua Yang, Wei Xiong, Fang Xu, Qijun Yuan, Xian Xiao, Renqiang Huang, Haihui Liang, Zhipeng Chen, Chuanyun Qian, Yang Li, Songqing Wang   +13 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Cold exposure induced oxidative stress and apoptosis in the myocardium by inhibiting the Nrf2-Keap1 signaling pathway

BMC Cardiovascular Disorders, 2018
Background Exposure to cold weather is associated with infaust cardiovascular responses, including myocardial infarction and arrhythmias. However, the exact mechanisms of these adverse changes in the myocardium under cold stress are unknown.
Peifang Cong, Yunen Liu, Nannan Liu, Yubiao Zhang, Changci Tong, Lin Shi, Xuelei Liu, Xiuyun Shi, Ying Liu, Zhou Tong, Mingxiao Hou   +10 more
doaj   +1 more source

A nomogramic model for predicting the left ventricular ejection fraction of STEMI patients after thrombolysis-transfer PCI

Frontiers in Cardiovascular Medicine, 2023
BackgroundThe prognosis of ST-segment elevation myocardial infarction (STEMI) is closely linked to left ventricular ejection fraction (LVEF). In contrast to primary percutaneous coronary intervention (PPCI), thrombolysis-transfer PCI (TTPCI) is ...
Shuai Liu, Shuai Liu, Shuai Liu, Zhihui Jiang, Zhihui Jiang, Zhihui Jiang, Yuanyuan Zhang, Shuwen Pang, Shuwen Pang, Yan Hou, Yipei Liu, Yipei Liu, Yuekang huang, Yuekang huang, Na Peng, Na Peng, Na Peng, Youqing Tang, Youqing Tang   +18 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function

Xiehe Yixue Zazhi
Disseminated intravascular coagulation (DIC) triggered by sepsis is a major challenge in the emergency and critical care of severely ill patients. The inflammasome is an essential component of the human immune system, and its activation can mediate ...
GAO Jiawei, DENG Xinkai, HAN Xiaobo, LI Xiao, CHAI Yahao, ZHANG Lei   +5 more
doaj   +1 more source