Results 41 to 50 of about 14,589,008 (193)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Other title: Chemical Spill and Radiation Emergency Notifications and the Emergency Planning and Community Right-to-Know Act.

, 1991
application/pdfA set of 18 documents provided by the Kansas Division of Emergency Management with resources and information on Chemical Spill/Radiation Emergency Notifications and the Emergency Planning and Community Right-to-Know Act.Chemical Planning ...
Kansas. Division of Emergency Management.
core   +1 more source

Multi-objective deep reinforcement learning for frequency emergency control with auxiliary voltage deviation mitigation

Energy and AI
This paper introduces a Multi-Objective Deep Reinforcement Learning framework for emergency control that addresses frequency–voltage coupling in modern power grids. By jointly achieving frequency security and voltage stability, the proposed scheme solely
Shengquan Lai, Liangcai Zhou, Xin Chen
doaj   +1 more source

Emergency obstacle avoidance trajectory tracking control based on active disturbance rejection for autonomous vehicles

International Journal of Advanced Robotic Systems, 2020
To solve the problem of understeer and oversteer for autonomous vehicle under high-speed emergency obstacle avoidance conditions, considering the effect of steering angular frequency and vehicle speed on yaw rate for four-wheel steering vehicles in the ...
Runqiao Liu, Minxiang Wei, Nan Sang
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Decentralized coordinated emergency frequency control strategy for renewables-rich power systems based on multi-agent reinforcement learning

International Journal of Electrical Power & Energy Systems
With the rapid growth of renewable energy in the power system and the implementation of high-capacity LCC-HVDC projects, the frequency support capability of the grid is decreasing. Existing centralized single-measurement methods and model-based emergency
Zhenglong Sun, Junpeng Han, Weihan Chen, Rui Zhang, Yong Liu, Yoash Levron, Juri Belikov   +6 more
doaj   +1 more source

Transient Frequency Stability Emergency Control for the Power System Interconnected With Offshore Wind Power Through VSC-HVDC

IEEE Access, 2020
For the power system interconnected with the large-scale offshore wind power through VSC-HVDC, such as SZ power grid, it may be engaged with transient frequency stability and lack of related control due to the randomness, fluctuation and intermittence of
Ancheng Xue, Jiahuan Zhang, Lijun Zhang, Yikai Sun, Jiehao Cui, Jiawei Wang   +5 more
doaj   +1 more source