Results 51 to 60 of about 14,589,008 (193)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Emergency coordinated control of multiple VSC‐HVDC for improving power system transient frequency and steady‐state frequency

IET Renewable Power Generation
With the penetration of the high proportion of power electronics interfaced energy resources, the frequency stability issue in power systems is becoming increasingly prominent. This paper proposes a coordinated control strategy of multiple voltage source
Xiaojing Chen, Haiying Dong, Yulong Che, Amin Huang   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The Quality of Pre-Hospital Emergency Care for Children with Acute Abdominal Pain: The Prospective Cohort Study Results

Педиатрическая фармакология, 2018
Background. Introduction of laboratory rapid tests into the practice of emergency teams (EMS) and carrying out a simple etiologic point-of-care diagnosis can affect the quality of medical care for children at subsequent stages. Objective.
Ekaterina A. Romanova, Leyla S. Namazova-Baranova, Elena Yu. Dyakonova, Aleksey Yu. Romanov   +3 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Cooperative Control to Enhance the Frequency Stability of Islanded Microgrids with DFIG-SMES

Energies, 2013
The issue of frequency stability of microgrids under islanded operation mode and mode transfer has attracted particular attention recently. In this paper, a cooperative frequency control method, which consists of a microgrid central control (MGCC) and ...
Wu Chen, Bo Zhao, Zhi Wu, Wei Liu, Wei Gu   +4 more
doaj   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Physics–Data Fusion-Driven Frequency Response Parameter Identification and Emergency Load Shedding in Renewable-Rich Power Systems

Energies
As renewable penetration increases, the inertia, damping, and primary frequency regulation characteristics of renewable-rich power systems become strongly time-varying, making fixed offline frequency response models increasingly difficult to maintain for
Qin Gao, Yingjie Chen, Yong Liu, Jianxin Zhang, Nan Zhang, Yong Mei   +5 more
doaj   +1 more source

Local and tribal emergency managers

, 2018
Began with May 1, 2018Mode of access: Internet from the Oregon Government Publications CollectionText in EnglishIssued by: Oregon Emergency Management, -May 2022; by: Oregon Department of Emergency Management, July 2022-This archived document is ...

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