Results 181 to 190 of about 631,916 (299)

Incarcerated Ventral Hernia Requiring Emergent Repair in an Adult With Down Syndrome: Diagnostic and Postoperative Challenges in an Underrepresented Population. [PDF]

Cureus
Khan Z, Jafri M, Lambroussis CG.
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Efficacy and safety of emergent balloon aortic valvuloplasty as a rescue therapy for cardiogenic shock due to severe aortic stenosis in non-TAVI centers. [PDF]

BMC Cardiovasc Disord
Masuda M, Fujimoto W, Iwasaki M, Uzu K, Sawa T, Kozuki A, Nishio R, Hiranuma N, Takemoto M, Kuroda K, Yamashita S, Imanishi J, Todoroki T, Okuda M, Otake H.   +14 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Thrombectomy with and without emergent stenting in acute ischemic stroke due to carotid artery dissection. [PDF]

Eur Stroke J
Kaindl L, Giannakakis M, Mbroh J, Gomez Exposito A, Krebs S, Hotz J, Miksova D, Katan M, Wegener S, De Marchis Gian M, Gattringer T, Deutschmann H, Mayer-Suess L, Fiehler J, Ernemann U, Hennersdorf F, Fischer U, Kulcsar Z, Mordasini P, Psychogios MN, Gizewski Elke R, Nolte C, Neumann C, Ferrari J, Dobrocky T, Poli S, Sykora M.   +26 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Emergent reactance induced by the deformation of a current-driven skyrmion lattice. [PDF]

Nat Commun
Littlehales MT, Birch MT, Kikkawa A, Taguchi Y, Alba Venero D, Hatton PD, Nagaosa N, Tokura Y, Yokouchi T.   +8 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Perioperative Management of Immune Thrombocytopenic Purpura in Cardiac Surgery: A Systematic Review of the Literature in Urgent and Elective Settings. [PDF]

Cureus
Said K, Kbiri H, El Baraka H, El Fassiki N, Bouchama A, Chouikh C, Elghoul N, Bencharfa B, Bouzari J, Fajri M, Sallahi H, Margad O, Benbouha A, Roukhsi R, El Ghadbane HA, Mohamed Amine A, Nabil M, Serghini I, Najout H, Salek M, Chlouchi A, Bentaher A, Ballouk R, Ababou M, Belfquih H, Bouhabba N, Elabdi M, Bouzerda A, Khatouri A, Qamouss Y, Zyani M.   +30 more
europepmc   +1 more source